Th. doct.-ing.--Électronique--Grenoble--I.N.P., 1982. N°: DI 313.

Thèse d'exercice : Médecine. Pédiatrie : Université de Nantes : 2004. / Bibliogr. f. 61-68.

Th. doct.-ing.--Électronique--Grenoble--I.N.P.G., 1981. N°: DI 246.

No description available.

Inaug. _ Diss.: Rechts- und staatswissenschaftliche Fakultät: Zürich: 1976. _ Bibliogr. p. VII-XIV.

Polyvinyl Chloride, commonly known as PVC is a common and effective construction material. PVC is also one of the most common types of plastic. In 2008, global production and consumption of PVC was approximately 34.5 million tons. The construction industry is responsible for about 70% of the world's consumption of PVC. The largest construction use of PVC is for pipe and conduit. Modern construction, especially structures built for data services depend heavily upon PVC conduit for underground pathways to distribute electricity and data. PVC is also at the center of a fierce effort by environmental groups who would like to see it eliminated completely. If environmentalists are successful in their efforts to eliminate PVC; builders will be left without a material that is crucial for many applications. Seven alternative conduit materials have been identified as potential replacements for PVC electrical conduit. PVC electrical conduit is commonly used in commercial, industrial, and civil construction. This thesis undertook to study the four major electrical contractors in the state of Utah which employ more than one hundred electricians. Because major electrical contractors use large quantities of PVC conduit, electricians working for these contractors were surveyed to determine their preferences of alternative materials. A questionnaire was distributed and received 112 responses, which represent 6.5% of the total population. This study found that PVC was the most used, most preferred, easiest to install and was perceived as the least expensive conduit material. Polypropylene and High Density Polyethylene were rated next highest, but were also the least commonly used of the alternative materials. The other materials, which include: Nylon, Fiberglass, Fiberglass Reinforced Epoxy, Polyurethane Coated Steel, and Galvanized Steel were also examined. Many of the respondents expressed displeasure by the effort to eliminate PVC and the vast majority felt that green certification for construction did not justify elimination. These responses indicate that more needs to be done to introduce alternative conduit materials to users of PVC and educate them about the value of the alternatives. This study represents an important step in evaluating the value of PVC conduit and its alternatives.

No description available.

The present study has developed poly ε-caprolactone (PCL)/ poly lactic acid (PLA) films with specific internal structure suitable to prepare nerve guide conduit for peripheral nerve repair. The film preparation method has been carried out using an environmental chamber to prepare the solvent cast films with the specific surface structure. Different cellular behaviour of neuronal cell cultures was seen on the pitted films with different pits configurations (size and distribution). The consistent surface morphology provided a reliable surface structure for further in vitro and in vivo studies. The effect of a medical grade sterilisation process using gamma radiation at eight doses (0-45kGy) on PCL/PLA films was explored. It has been shown that material properties, including mechanical strength, were significantly affected, while cellular behaviour and responses (NG108-15) were improved. Grooved films with three groove shapes (Sloped, Square, and V shape) were prepared using patterned silicon substrates, photolithography and wet/dry etching. The groove patterns were successfully transferred and good mechanical strength was observed for grooved PCL/ PLA. Oriented growth of NG108-15 cells was observed on the patterned films with an improved alignment and organisation on SL and V shape grooved films. UV-ozone treatment was used to increase hydrophilicity of PCL/PLA films to improve Schwann cells behaviour. No negative effect was observed on cell growth and proliferation on the treated films however the mechanical properties were reduced. Schwann cells expressed typical long spindle-shape morphology with cell-to-cell interaction in longitudinal direction on the treated grooved films. Consistent to in vitro experiment with NG108-15, Schwann cells alignment was also improved on SL and V shape grooves. A three-week in vivo study was carried out to test grooved and non-grooved conduits in a rat sciatic nerve model. The grooved conduits showed better regeneration, with SL-grooved film showing a significant improvement of nerve regeneration. A separate in vivo study evaluated the effect of wall-thickness on nerve regeneration. However, it was shown that the wall thickness had no positive effect, and the conduit with improved mechanical strength adversely affected the nerve regeneration. In conclusion, a nerve guide conduit was developed with the optimised surface structure to support nerve regeneration. The promising in vitro and in vivo studies together with the suitable biomechanical properties and specific surface structure and morphology indicate that the grooved PCL/PLA conduit is a viable treatment for peripheral nerve repair.

Flow mediated dilation (FMD) is a non-invasive test that assesses endothelial health and nitric oxide bioavailability; it is commonly used to examine changes in vascular health due to disease or de-conditioning. Currently, a wide variety of protocols are being used to assess upper and lower extremity conduit artery health. The current project was embarked upon to gain a better understanding of the FMD protocols currently being used to asses conduit artery FMD and how these results impact our understanding of a participant’s vascular health. More specifically occlusion duration, cuff placement and artery location were examined in three commonly examined conduit arteries. The FMD responses in the brachial artery (BA), superficial femoral artery (SFA), and popliteal artery (PA) of ten healthy men, mean age of 27, after five and/or two-minutes of distal occlusion were examined. When the two-minute protocol was performed on the SFA and PA, low-resistance static calf exercise was added to augment the shear stimulus. It was hypothesized that percent FMD and shear stress responses of the SFA and PA would not be significantly different after five-minutes of occlusion, thereby allowing leg conduit artery FMD to be performed on either artery. It was further hypothesized that there would be no significant differences between the shear stress and percent FMD responses of the leg conduit arteries after five or two-minutes of occlusion; inferring that shorter occlusion durations when combines with ischemic muscle contractions can be used to assess SFA or PA FMD. With regards to comparisons between arm and leg conduit arteries, it was hypothesized that there would be significant between limb differences in baseline diameter, FMD and shear stress post five-minutes of distal occlusion. These differences will be used to better understand the effects of artery location and size on conduit artery FMD IV responses. Limitations with the traditional edge-detection method of determining arterial diameter prompted the creation of a new method of measuring artery diameter, the center-based method. It was hypothesized that there would be no significant differences in the percent FMD and time to FMD after five-minutes of BA occlusion (n=7). The results of the current study demonstrated that five-minutes of calf occlusion elicited a significant PA FMD but not a significant SFA FMD. FMD post two-minutes of PA occlusion with exercise was not significantly different than that produced by five-minutes of occlusion. Conversely, two-minutes of calf occlusion with exercise was unable to elicit a SFA FMD response. Significant differences in shear stress and FMD were reported between arm and leg conduit arteries, demonstrating different responses to five-minutes of distal occlusion due to artery size and location. Finally, no significant differences were noted between FMD and time to FMD when the center-based or edge-detection method was used. This study has demonstrated that the calf occlusion protocol was unable to elicit a FMD response in the SFA FMD; this occlusion location is only able to elicit a PA FMD response. Furthermore, two-minutes of occlusion with one-minute of exercise can be used in place of the five-minute protocol to examine PA FMD but not SFA FMD. Differences between arm and leg conduit arteries are noted and it has been suggested that this is likely due to leg conduit artery adaptations to gravity. Lastly, preliminary data suggest that the center-based method is an appropriate method of measuring conduit artery diameter.

Fluid drainage via the lymphatics prevents swelling due to excess fluid in interstitial space. Since interstitial fluid volume can vary dramatically, the function of lymphangions are rather dynamic so that they can contend with the wide ranges of lymph flow and pressure. Sharing with blood vessels an acute sensitivity to mechanical stresses, lymphangions could be expected to be similarly sensitive to prolonged changes in transmural pressure and flow. The purpose of this research was to quantify the adaptation of lymphangions to prolonged alterations in lymph hydrodynamics and to investigate how adaptation of individual lymphangions acts together within a network to affect the regulation of lymph flow. In project I, bovine postnodal mesenteric lymphatic vessels were partially occluded for three days, which divided the vessel into two segments. Both segments, therefore, were exposed to the same flow but different transmural pressures. In project II, an isometric preparation was employed to study developed wall tension in lymphangions exposed to mesenteric venous hypertension. In project III, an analytical model of a symmetrical lymphatic network was developed to investigate how its pressure-flow relationship emerges from the complex interaction of its pumping lymphangions. Results from this research indicate that lymphangions become stronger pumps when exposed to prolonged increases in transmural pressure, but exposure to prolonged venous hypertension attenuates lymphangion pumping. The main mechanism for lymphangion adaptation is the alteration of preload-dependent maximal tension developed by lymphatic muscle. Lower cytosolic Ca2+ concentration is likely to be the underlying cause for weaker developed tension. The analytical model suggests that the ratio of lymphangion systolic contractility to diastolic stiffness results in a differential response of lymph flow to changes in inlet and outlet pressures. This differential sensitivity to inlet and outlet pressures allows homeostatic responses to both microvascular and venous hypertension, and provides a framework for interpreting the functional implications of chronic lymphangion adaption.