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Certain characteristics of connective tissue and factors which affect them in mammalsBray, R. W. January 1949 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1949. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 64-67).
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Mass spectrometric characterisation of the 3-hydroxy-pyridinium collagen cross-link molecules and derivativesShield, Tracey Louise January 1997 (has links)
No description available.
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Cysteine (C)-X-C Receptor 4 undergoes Transportin 1-Dependent Nuclear Localization and remains functional at the Nucleus of Metastatic Prostate Cancer CellsDon-Salu-Hewage, Ayesha Shyamali 01 July 2013 (has links)
The G-protein coupled receptor (GPCR) Cysteine (C)-X-C Receptor 4 (CXCR4) plays an important role in prostate cancer metastasis. CXCR4 is regarded as a plasma membrane receptor, that it transmits signals that support transformation, progression and metastasis. Due to the central role of CXCR4 in tumorigenesis, therapeutic approaches such as antagonists and monoclonal antibodies have focused on receptors the located at the plasma membrane. An emerging concept for GPCRs is that they can localize to the nucleus where they may retain function and mediate nuclear signaling. Herein, we demonstrate that CXCR4 is highly expressed in high grade metastatic prostate cancer tissues. Increased expression of CXCR4 is also detected in several prostate cancer cell lines as compared to normal prostate epithelial cells. Our studies identify a nuclear pool of CXCR4 and also define a mechanism for nuclear targeting of CXCR4. A classical nuclear localization sequence (cNLS), "RPRK", in CXCR4 can contribute to nuclear localization. In addition, CXCR4 interacts with the nuclear transport receptor, Transportin βi, to promote nuclear accumulation of CXCR4. Importantly, Gαi immunoprecipitation and calcium mobilization studies indicate that nuclear CXCR4 is functional and can participate in G-protein signaling revealing that the nuclear pool of CXCR4 can retain function. Localization of functional CXCR4 to the nucleus may be a mechanism by which prostate cancer cells evade treatment, thus contributing to increased metastatic ability and poorer prognosis after tumors have been treated with therapy that targets plasma membrane CXCR4. This study addresses the mechanism of nuclear targeting for CXCR4 and demonstrates that CXCR4 can retain function within the nucleus and provides important new information to illuminate what have previously been primarily clinical observations of nuclear CXCR4.
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A quantitative radioautographic study of the effect of anoxic stress on H³-proline incorporation by oral connective tissue cells in the hamster neonateSmith, Donald M. January 1967 (has links)
Thesis (M.S.)--University of Michigan, Ann Arbor, 1967. / Typescript (photocopy). Includes bibliographical references (leaves 25-31). Also issued in print.
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A quantitative radioautographic study of the effect of anoxic stress on H³-proline incorporation by oral connective tissue cells in the hamster neonateSmith, Donald M. January 1967 (has links)
Thesis (M.S.)--University of Michigan, Ann Arbor, 1967. / Typescript (photocopy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 25-31).
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The molecular genetics of the Ehlers-Danlos syndrome types I and IIBurrows, Nigel Peter January 1999 (has links)
No description available.
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Identification and characterization of type II collagen mutations /Bogaert, Raymond, January 1998 (has links)
Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographical references (leaves [118]-127).
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Cortical bone tissue engineering scaffold design and cell selection /Wen, Demin. January 2009 (has links)
Thesis (D.Eng.)--Cleveland State University, 2009. / Abstract. Title from PDF t.p. (viewed on Jan. 13, 2010). Includes bibliographical references (p. 139-151). Available online via the OhioLINK ETD Center and also available in print.
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Biochemical and biological characterization of normal skin fibroblasts from individuals predisposed to dominantly inherited cancersAntecol, Michael Hal. January 1985 (has links)
No description available.
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In vitro derivation of myelinatiog Schwann cells for use in chitosan-based nerve guidance channelsTsui, Yat-ping. January 2009 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2009. / Includes bibliographical references (p. 92-108) Also available in print.
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