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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating cells in vivo

Francoz, Sarah S 02 June 2006 (has links)
The Mdm2 and Mdm4 oncoproteins are key negative regulators of the p53 tumor suppressor. However, their physiological contributions to the regulation of p53 stability and activity remain highly controversial. Here, we combined a p53 knock-in allele, in which p53 is silenced by a transcriptional stop element flanked by loxP sites, with the Mdm2- and Mdm4-null alleles. This approach allows Cre-mediated conditional p53 expression in tissues in vivo and cells in vitro lacking Mdm2, Mdm4, or both. Using this strategy, we show that Mdm2 and Mdm4 are essential in a nonredundant manner for preventing p53 activity in the same cell type (Mouse Embryonic Fibroblasts (MEFs), neuronal progenitor cells and postmitotic neurons) and irrespective of the proliferation/differentiation status of the cells. Although Mdm2 prevents accumulation of the p53 protein, Mdm4 contributes to the overall inhibition of p53 activity independent of Mdm2. We propose a model in which Mdm2 is critical for the regulation of p53 levels and Mdm4 is critical for the fine-tuning of p53 transcriptional activity, both proteins acting synergistically to keep p53 in check. Finally, we show that neither Mdm2 nor Mdm4 regulate cell cycle progression independently of its ability to modulate p53 function.

Bilan d'extension et évaluation de la réponse au traitement dans les tumeurs de la famille d'Ewing

Lefrançois, Thomas Dupas, Benoît. January 2004 (has links) (PDF)
Thèse d'exercice : Médecine. Imagerie médicale : Université de Nantes : 2004. / Bibliogr. f. 150-156 [114 réf.].

Chemical transformation and chromosomal analysis of fibroblasts from patients genetically predisposed to cancer

Danielson, Donna Mary, January 1976 (has links)
Thesis--Wisconsin. / Includes bibliographical references (leaves 60-72).

Investigation of redox-active ruthenium(II) polypyridyl complexes as potential anti-cancer drugs

Yadav, Abhishek. January 2008 (has links)
Thesis (Ph.D.) -- University of Texas at Arlington, 2008.

The Insider and Outsider Perspective clinical importance of agreement between patients and nurses in cancer care concerning patients' emotional distress, coping resources and quality of life /

Mårtensson, Gunilla, January 2009 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2009. / Härtill 4 uppsatser.

Development of an ACR Appropriateness Criteria database

Belliappa, Goutham, January 2001 (has links) (PDF)
Thesis (M.S.)--University of Florida, 2001. / Title from first page of PDF file. Document formatted into pages; contains viii, 138 p.; also contains graphics. Vita. Includes bibliographical references (p. 136-137).

Discovery of novel downstream target genes regulated by the hedgehog pathway /

Ingram, Wendy Jill. January 2002 (has links)
Thesis (Ph. D.)--University of Queensland, 2003. / Includes bibliographical references.

Vocational rehabilitation and cancer is vocational rehabilitation ready for the challenges cancer assumes as a disability? /

Ruckman, Sara E. January 2002 (has links) (PDF)
Thesis--PlanB (M.S.)--University of Wisconsin--Stout, 2002. / Includes bibliographical references.

Problems encountered in caring for patients with terminal cancer at home which result in a request for institutional care

Detmer, Sarah Stuard. January 1967 (has links)
Thesis (M.S.)--Catholic University of America. / Includes bibliographical references.

New algorithms for target delineation and radiation delivery in intensity-modulated radiation therapy

Dou, Xin. Wu, Xiaodong, January 2009 (has links)
Thesis supervisor: Xiaodong Wu. Includes bibliographic references (p. 170-177).

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