Thesis (Ph. D.)--Washington State University, May 2009. / Title from PDF title page (viewed on June 15, 2009). "School of Molecular Biosciences." Includes bibliographical references.

Thesis (Ph. D.)--Drexel University, 2004. / Includes abstract and vita. Includes bibliographical references (leaves 115-125).

Thesis (Ph. D.)--University of Hong Kong, 1998. / Includes bibliographical references (leaves 272-287).

Thesis (Ph. D.)--Rutgers University, 2008. / "Graduate Program in Pharmaceutical Science." Includes bibliographical references (p. 311-331).

Thesis (M.Med.Sc.)--University of Hong Kong, 2002. / Includes bibliographical references (leaves 83-101). Also available in print.

Thesis (Ph. D.)--University of Florida, 1985. / Description based on print version record. Typescript. Vita. Includes bibliographical references (leaves 205-214).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1983. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 70-73).

Thesis (M. Med. Sc.)--University of Hong Kong, 2005.

Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2007. / Includes bibliographical references (leaves 151-166). Also available in electronic version.

Les chiffres mondiaux estiment l’incidence du cancer du sein, cancer féminin le plus fréquent, à 1.3 millions de cas par an, dont près d’un tiers a une issue fatale.La polarité est indispensable à l’organisation cellulaire, ses défauts peuvent mener au cancer. Notre projet est focalisé sur une protéine de la polarité, Lano, et son influence sur le cancer du sein et les CSC. L’Institut Paoli-Calmettes dispose d’environ 10000 échantillons de cancer du sein dont l’analyse montre que la perte de Lano est corrélée à des cancers du sein plus graves et à une augmentation des CSC. Nos résultats in vitro, sur des cellules de cancer du sein humain et in vivo montrent aussi que Lano est un régulateur du nombre de CSC. Les CSC sont une ces causes principales de rechute des patients. La suite de nos travaux pourrait déterminer si Lano est un facteur pronostique de la maladie ou une cible thérapeutique possible. / Breast cancer is the most common cancer in women. Worldwide figures estimate the incidence of breast cancer at 1.3 million cases per year, nearly one third of them has a fatal outcome.Our project focuses on the study of Lano, a polarity protein, in breast cancer and stem cells. The hospital “Institute Paoli-Calmettes” gathered 10,000 breast cancer samples whose analysis shows that the loss of Lano has a role in breast cancer and stem cells. Our in vitro results on human breast cancer cells and in vivo also show that Lano is a regulator of the number of cancer stem cells. Cancer stem cells are one of the major causes of relapse in patients. The rest of our work could determine if Lano could be a prognostic factor of the disease or a possible therapeutic target.