The National Comprehensive Cancer Network identified occupational therapy as a first line of intervention for the treatment of cancer-related cognitive dysfunction (CRCD) (National Comprehensive Cancer Network [NCCN], 2016). Thus, occupational therapists have an opportunity to develop interventions that facilitate participation in meaningful occupations for survivors of cancer living with CRCD. In this article, we argue for occupational therapists to create occupation- and evidence-based, client-centered interventions for survivors of cancer with CRCD that address the multidimensional presentation of CRCD. One survivor’s story illustrates the affect of CRCD on occupational performance and the features to consider when developing interventions to meet the unique needs of survivors of cancer with CRCD. We recommend that interventions can be provided through self-paced home programming, community settings, or delivered through modes such as tele-rehabilitation to reach the growing population of survivors of cancer.