Several registered and exploratory herbicides were effective for broadleaved weed control when applied preplant incorporated or preemergence in cantaloupes. Bensulide (Preface), clomazone (Command®), cyanazine (Bladex®), dimethanamid (Frontier®), ethafluralin (Curbit®), metolachlor (Dual ®), pendimethalin (Prowl®), trifluralin, dithiopyr (Rohm and Haas), and thiazopyr (Rohm and Haas) gave marginally acceptable control of most weeds. Crop injury was observed for some treatments of Frontier, Prowl, napropamide (Devrinol®), and Command. As the season progressed, groundcherry (Physalis wrightii) was not adequately controlled by any treatment.