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1	Carbohydrate Synthesis and Study of Carbohydrate-Lectin Interactions Using QCM Biosensors and Microarray Technologies Pei, Zhichao January 2006 (has links) Interactions between carbohydrates and proteins are increasingly being recognized as crucial in many biological processes, such as cellular adhesion and communication. In order to investigate the interactions of carbohydrates and proteins, the development of efficient analytic technologies, as well as novel strategies for the synthesis of carbohydrates, have to be explored. To date, several methods have been exploited to analyze interactions of carbohydrates and proteins, for example, biosensors, nuclear magnetic resonance (NMR); enzyme-linked immunosorbent assays (ELISA), X-ray crystallography and array technologies. This thesis describes the development of novel strategies for the synthesis of carbohydrates, as well as new efficient strategies to Quartz Crystal Microbalance- (QCM-) biosensors and carbohydrate microarrays technologies. These methodologies have been used to probe carbohydrate-lectin-interactions for a range of plant and animal lectins. / QC 20100915 Organic chemistry Organisk kemi
2	Photochemical Surface Functionalization : Synthesis, Nanochemistry and Glycobiological Studies Deng, Lingquan January 2011 (has links) This thesis mainly deals with the development of photochemical approaches to immobilize carbohydrates on surfaces for glycobiological studies. These approaches have been incorporated into a number of state-of-the-art nanobio-platforms, including carbohydrate microarrays, surface plasmon resonance (SPR), quartz crystal microbalance (QCM), atomic force microscopy (AFM), and glyconanomaterials. All the surfaces have displayed good binding capabilities and selectivities after functionalization with carbohydrates, and a range of important data have been obtained concerning surface characteristics and carbohydrate-protein interactions, based on the platforms established. Besides, a variety of non-carbohydrate and carbohydrate-based molecules have been synthesized, during which process the mutarotation of 1-glycosyl thiols and the stereocontrol in 1-S-glycosylation reactions have been thoroughly studied. / QC 20111004 Carbohydrates Glycobiology Carbohydrate-protein interactions Perfluorophenylazide (PFPA) Photochemistry Carbohydrate surface immobilization Carbohydrate microarrays Surface plasmon resonance (SPR) Quartz crystal microbalance (QCM) Atomic force microscopy (AFM) Glyconanomaterials Concanavalin A (Con A) Cyanovirin-N (CV-N) 1-Glycosyl thiols; Mutarotation 1-S-glycosylation Stereocontrol

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Carbohydrate Synthesis and Study of Carbohydrate-Lectin Interactions Using QCM Biosensors and Microarray Technologies

Photochemical Surface Functionalization : Synthesis, Nanochemistry and Glycobiological Studies