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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Synthesis of antimicrobial peptides derived from BP100 and BPC194

Güell Costa, Imma 27 January 2012 (has links)
In the present PhD thesis we studied the solid-phase peptide synthesis of antimicrobial peptides derived from the lead peptides BP100 and BPC194. First, peptides derived from BP100 containing D-amino acids at different positions of the sequences were prepared. Moreover, peptidotriazoles derived from BP100 were also synthesized containing the triazole ring at the side-chain of different amino acids. Then, we proceeded to perform studies for the synthesis of multivalent peptides derived from BPC194. To achieve this objective, the synthesis of cyclic peptides containig a triazole ring at amino acids side-chain with different elongations was carried out. Finally, we prepared various carbopeptides containing 2 and 4 units of BP100 and/or its derivatives. The evaluation of the biological activity allowed the identification of active sequences against the economically important phytopathogenic bacteria and fungi and not toxic against eukaryotic cells. / En aquesta tesi doctoral es va estudiar la preparació en fase sòlida de pèptids antimicrobians derivats dels pèptids lead BP100 i BPC194. En primer lloc, es varen preparar derivats del pèptid lineal BP100 incorporant D aminoàcids en diferents posicions de la seqüència. A més, també es varen sintetitzar derivats d'aquest pèptid lead incorporant un anell de triazole a la cadena lateral de diferents aminoàcids. Posteriorment, es va procedir a l'estudi de la síntesi dd pèptids multivalents derivats de BPC194. Per aconseguir aquest objectiu es va portar a terme la síntesi de pèptids cíclics incorporant un anell de triazole a la cadena lateral d’aminoàcids amb diferents allargades de cadena. Finalment, va procedir a la preparació de carbopèptids contenint 2 i 4 unitats de BP100 i/o derivats. L’avaluació de l’activitat biològica dels pèptids sintetitzats va permetre idenficar seqüències actives enfront de bacteris fitopatògens i fongs i poc tòxiques enfront cèl•lules eucariotes.

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