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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Effect of an Educational Intervention on Cardiovascular Disease Risk Perception Among Women With Preeclampsia

Spratling, Patsy M., Pryor, Erica R., Moneyham, Linda D., Hodges, Ashley L., White-Williams, Connie L., Martin, James N. 01 January 2014 (has links)
Objective: To promote knowledge and awareness about cardiovascular disease (CVD) among women with recent preeclampsia so that this population may develop more accurate perceptions of their personal CVD risk. Design: An exploratory single group, pretest/posttest educational intervention study. Setting: Telephone-based interviews. Participants: Sixty-four women with preeclampsia in the most recent pregnancy completed the study. The sample was predominately African American. Methods: Knowledge about CVD and the study covariates (age, race, parity, income, marital status, education, and history of previous preeclampsia) were measured prior to CVD education. Levels of CVD risk perception were measured both before and after the CVD educational intervention. Intervention: Structured CVD education by telephone. Results: After CVD education, levels of CVD risk perception were significantly higher than at baseline. Conclusion: As an intervention, CVD education provided by telephone served as a practical and effective approach to contact postpartum women with recent preeclampsia and demonstrated effectiveness in increasing perception of CVD risk.

The impact of ovariectomy on the sympathetic response following acute vs prolonged heart failure

Sosebee, Sarah, Billings, Eliza, Paul, Chloe, Phipps, Madison, Young, Brodi, Singh, Krishna, Foster, Cerrone 25 April 2023 (has links)
Currently cardiovascular disease (CVD) is the leading cause of death globally accounting for nearly 17.9 million deaths every year. Studies show that CVD affects men and women differently. A significant increase in CVD incidence is marked by the onset of menopause in women compared to age matched males. A commonality seen in CVD is the use of ꞵ-adrenergic receptors (ꞵ-ARs), as studies have shown that estrogen loss exacerbates the signaling of these ꞵ-AR’s. Changes within this signaling molecule can lead to structural and functional modifications in the heart, including systolic or diastolic dysfunction. This leads to the hypothesis that estrogen loss exacerbates cardiac function with acute sympathetic stimulation and hypertrophy, but prolonged stimulation blunts the sympathetic response. Female mice were ovariectomized (OVX) or underwent SHAM surgery at 2.5 months of age. These mice were treated with isoproterenol (ISO) to simulate chronic sympathetic stimulation for 7, 14, 21 and 28 days continuously through mini osmotic pumps 3 months post ovariectomy. Echocardiography parameters were analyzed using diastolic diameter (DD), systolic diameter (SD), fractional shorting (%FS), and ejection fraction (%EF). Preliminary results showed that %FS and %EF did not change in the OVX and ISO groups compared to SHAM at 7, 14, and 28 days. Similar results were observed in the OVX compared to ISO + OVX groups at 7 days. Even though %FS and %EF did not change, the DD increased at all time points in OVX and ISO groups compared to SHAM. When comparing OVX and ISO + OVX, SD decreased at 14 and 21 days. There is however a significant increase in %FS and %EF at 21 days for all treatment groups. These preliminary results give a better insight to heart function over the course of multiple time points, suggesting that estrogen loss combined with chronic sympathetic stimulation significantly exacerbates the function of the heart.

A collaborative undergraduate research project to assess the effects of prolonged estrogen loss on cardiovascular structure and function in female mice

Phipps, Madison, Brackett, Skylar M, Billings, Eliza, Ogilvie, Libbie, Holley, Adam, Glover, Kyler, Paul, Chloe, Sosebee, Sarah, Williams, Patra, Guy, Amanda, Sawyer, Bailey, Woods, Laken, Hargrove, Aly, Eslick, Camden, Clem, Rachel, Neal, Madisyn, Britt, Madison, Price, Crimsyn, Chikomb, Sally, Westbrook, Marlee, Yobst, Ava, Paige, Cody, Aninyei, Fumnanya, Young, Brodi, Coleman, Lejua, Singh, Krishna, Foster, Cerrone 25 April 2023 (has links)
Cardiovascular disease is a worldwide problem for both men and women and accounts for nearly 17.9 million deaths every year. Cardiovascular disease affects men and women differently and has resulted in more deaths in women since the 1980’s. Estrogen status decreases with age and as women go through menopause, it increases the burden of CVD events. Clinical studies have shown that estrogen can have cardioprotective effects via its receptors. These receptors binding causes pleotropic affects in signaling to maintain cardiovascular homeostasis. There are limited studies on estrogen loss in the aging heart over a continuous span. We therefore examined the effects of estrogen loss and its role in cardiac structure and function over time in female mice. This research was a collaborative project by 25 undergraduate students. Studies have shown undergraduate research to be extremely useful in improving undergraduate students’ analytical, communication, statistical knowledge, and other scientific and laboratory skills (Tan et al., 2022). During this lab, students performed various histological staining methods, analysis of echocardiograms, and animal research. Female mice were ovariectomized at 2.5 months of age or underwent a SHAM (mock) surgery. Echocardiography was preformed to examine the cardiac structure and function at 1, 3, 5, 12, and 18 months post ovariectomy. Hearts were removed at each time point and sectioned at 4µm thick. Cardiac hypotrophy was then assessed by histological staining using Wheat Germ Agglutin and myocyte cross-sectional area was measured of the stained images. There was a significant increase in cardiac hypertrophy in the 1-month versus 18-month SHAM and OVX groups. Also, there was a significant increase in cardiac hypertrophy between the SHAM and OVX groups at 1-month, 3-month, and 5-month OVX. Echocardiography results revealed significant increases in the diastolic (DD) and systolic diameter (SD) for the SHAM and OVX group at 1-month versus 18-month. Percent Fractional (%FS), and Ejection Fraction (EF) were significantly higher in the OVX group versus SHAM at 1, 5, and 18-month time points. This work highlights the impact of prolonged estrogen loss on changes in cardiac structure and function in the aging female heart.

Evaluation of cardiovascular risk and endothelial function in hypopituitarism

Abdu, Tarig Abdu Mohamed January 2003 (has links)
Adult hypopituitarism is associated with increased mortality and morbidity mostly from cardiovascular disease. This thesis examines lipid profile, coronary risk, homocysteine level and endothelial function in a group of hypopituitary patients compared to matched controls. Triglycerides, total and LDL-cholesterol were elevated in patients of both genders; HDL-cholesterol was significantly reduced in females. HDL-cholesterol correlated negatively with adiposity. Total to HDL-cholesterol ratio was increased in both genders. The lipid abnormalities appear to be related to GH-deficiency either directly (LDL) or indirectly through increased central obesity (HDL). Absolute 5-years risk of a coronary event, using the Framingham risk equation, was greater in patients. Relative risk (RR) was higher in patients but not in the controls, mostly because female patients had significantly higher RR. RR for controls was not different from the local population. Lipid changes explained the increased risk in patients, particularly females. Plasma homocysteine was not increased in hypopituitary patients, and therefore does not appear to contribute to the increased cardiovascular mortality. Biochemical markers of endothelial dysfunction, e-selectin, ICAM-1, TM, and vWF, were higher in patients. Brachial artery EDD was lower in patients than controls. This difference in EDD was more marked in females, though it disappeared when comparing the oestrogen sufficient female patients with controls. However, the female patients who were not replaced with oestrogen continued to show a striking difference compared to oestrogen deficient control females, There was no difference in carotid IMT between patients of both genders and controls. EDD correlated inversely with ICAM-1; ICAM-1 correlated positively with e-selectin and negatively with IGF-1; e-selectin correlated positively with TM, vWF, and negatively with IGF-1; TM correlated positively with vWF and inversely with IGF-1. The results confirm significant endothelial dysfunction in hypopituitarism and suggest a role for GH-deficiency and oestrogen deficiency in endothelial dysfunction.

Conduit artery changes in uraemia

Savage, Maria Theresa January 1999 (has links)
No description available.

The influence of dihydropyridines on the transvascular movement of atherogenic plasma proteins

Farmer, Hayley January 1999 (has links)
No description available.

The angiotensinogen gene in human essential hypertension

Caulfield, Mark Jonathan January 1996 (has links)
No description available.

Photodynamic therapy in the management of angioplasty restenosis

Nyamekye, Isaac January 1995 (has links)
No description available.

Investigations into the optimal management of hypertension

Dickerson, Josephine Ellen Claire January 1997 (has links)
No description available.

Nutritional influences on development of the cardiovascular system and the hypothalamic-pituitary-adrenal axis

Hawkins, Paul January 1999 (has links)
No description available.

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