Global ETD Search

1	Q-VE-OPh, a control caspase inhibitor for analyzing neuronal death Bricker, Rebecca L. 28 June 2012 (has links) No description available. Biology Chemistry Pharmacology sarin neuronal death immunohistochemistry analysis caspase inhibitor
2	Optimization of In Vitro Cultures of Neonatal Porcine Islets Pre-transplantation Sidhu, Satinder K. Unknown Date No description available. Neonatal porcine islets Islet xenotransplantation Neonatal porcine islet cultures Caspase inhibitor Protease inhibitor
3	Optimization of In Vitro Cultures of Neonatal Porcine Islets Pre-transplantation Sidhu, Satinder K. 11 1900 (has links) Islet transplantation is an attractive method to achieve blood glucose homeostasis. However, β-cell function declines over time. Therefore, it is necessary to explore strategies to enhance the β-cell mass and function. Also, because there is a severe shortage of human cadaver tissue, alternative sources of insulin secreting tissue need to be examined. Neonatal porcine islet (NPI) tissue has emerged as an attractive alternative source of β-cells. The aim of this thesis was to optimize the culturing conditions of NPIs pre-transplantation so that the available tissue can be used as efficiently and economically as possible. The results from this study indicate that the treatment of NPI cultures with z-VAD-FMK, a pan caspase inhibitor and general protease inhibitor significantly enhances β-cell survival. Additionally, the optimum length of culturing NPIs pre-transplantation appears to be 3-5 days. Since widespread cell death stimulates immunogenic response, this treatment also has the potential benefit of reducing immunosuppression needs in the recipient. / Experimental Surgery Neonatal porcine islets Islet xenotransplantation Neonatal porcine islet cultures Caspase inhibitor Protease inhibitor
4	Novel Trisubstituted Arylidene Oxindoles with Potent Anti-Apoptotic Properties Repasky, Paul J. 11 July 2011 (has links) No description available. Biochemistry Biology Chemistry Molecular Biology Molecular Chemistry Organic Chemistry organic chemistry oxindole benzylidene arylidene caspase caspase inhibitor indole small molecule apoptosis DNA ladder
5	Synthesis of Isatin Derivatives Used for the Inhibition of Pro-Apoptotic Jurkat T Cells Clay, Charles Michael 16 September 2011 (has links) No description available. Chemistry Isatin Oxindole Benzylidene N-alkylation Knoevenagel condensation Wolff-Kishner reduction Apoptosis Caspases Caspase inhibitor small molecule inhibitor Biological Screening DNA laddering Q-VD-OPh

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