Spelling suggestions: "subject:"well 1interaction"" "subject:"well aninteraction""
1 |
Beta-catenin signaling in the interactions of tumor cells and the tumor microenvironmentTo, Kit-yan, 杜潔欣 January 2015 (has links)
abstract / Biological Sciences / Doctoral / Doctor of Philosophy
|
2 |
Biomolecular and cellular interactions with surfacesLord, Megan Susan, Graduate School of Biomedical Engineering, Faculty of Engineering, UNSW January 2006 (has links)
The modulation of biological interactions with artificial surfaces is a vital aspect of biomaterials research. Protein adsorption is established as an early biological response to implanted materials that influences biocompatibility, hence an understanding of how to direct specific protein and cellular responses is critical for the development of future biomaterials. The effects of protein adsorption and subsequent cellular interactions on a variety of surfaces are investigated. Acrylic-based hydrogels are used as a model system in which to investigate both tear and serum protein adsorption from simple and complex solutions. The effect of surface topography, created by colloidal silica, on serum protein adsorption and conformation as well as cell adhesion is also investigated. Tantalum (Ta) and oxidised polystyrene (PSox) are investigated for their ability to support cell adhesion when precoated with various serum proteins. Protein interactions are examined using a combination of quartz crystal microbalance with dissipation (QCM-D), surface plasmon resonance (SPR), dual polarisation interferometry (DPI) and enzyme-linked immunosorbent assay (ELISA) while cellular interactions are analysed using QCM-D, microscopy and adhesion assays. The QCM-D technique was evaluated for its ability to provide new insight into cell-surface interactions. Most tear and serum proteins were found to adsorb onto the acrylic hydrogels, however, lysozyme was found to absorb into the hydrogel matrix and decrease the hydration, which may lead to an adverse biological response. Fibronectin adsorbed onto nanotextured colloidal silica surfaces was found to be conformationally changed compared to flat controls which is likely to correlate with the reduced endothelial cell adhesion observed on these textured surfaces. Ta and PSox precoated with either serum or fibronectin were shown to support cell adhesion and spreading, while surfaces precoated with albumin were not. QCM-D responses varied between underlying surfaces, protein precoating, ECM deposition, cytoskeletal activity and length of exposure indicating that alterations in cell-material responses are reflected in QCM-D measurements. QCM-D parameters were found to correlate with adhered cell numbers, cell contact area and cytoskeletal activity. The results highlight that characterisation of interfacial interactions with a wide range of analytical techniques is necessary to gain insight into cell-protein-material interactions which can then be utilised in the development of new generations of biomaterials with improved properties designed for specific applications.
|
3 |
Protein Tyrosine Phosphatase Pez : its role in the regulation of cell-cell adhesionsWadham, Carol. January 2003 (has links) (PDF)
"March 2003" Bibliography: leaves 206-233. The experimental data presented in this thesis provide evidence that PTP-Pez is an active phosphatase that interacts with and dephosphorylates the adherens junction protein ℓ-catenin. PTP-Pez also associates with proteins that form part of the tight junction complex, the scaffolding protein ZO-1 and the transmembrane protein occludin.
|
4 |
Development of redox microphysiometry to assay cell signaling and metabolism /Johnson, Jenifer L. January 2001 (has links)
Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 75-79).
|
5 |
Regulation of testicular cell junction dynamicsZhang, Xu, 张栩 January 2014 (has links)
abstract / Biological Sciences / Doctoral / Doctor of Philosophy
|
6 |
Drosophila Rhomboid-1 defines a widely-conserved family of intramembrane serine proteases involved in initiating intercellular communicationUrban, Sinisa January 2002 (has links)
No description available.
|
7 |
Effects of ammonium ion an culturing mode on protein production from endocrine cell culturesDyken, Jill Jeanne 08 1900 (has links)
No description available.
|
8 |
Protein Tyrosine Phosphatase Pez : its role in the regulation of cell-cell adhesions /Wadham, Carol. January 2003 (has links) (PDF)
Thesis (Ph.D.) -- University of Adelaide, Dept. of Medicine, 2003. / "March 2003" Bibliography: leaves 206-233.
|
9 |
Profiling of cell-substrate interactions using single cell fluororeporter imaging & modelingTresier, Matthew David, January 2009 (has links)
Thesis (Ph. D.)--Rutgers University, 2009. / "Graduate Program in Biomedical Engineering." Includes bibliographical references (p. 186-211).
|
10 |
Evaluation of intercellular signaling in Legionella pneumophilaZeigler-Ballerstein, Stephanie Denise. Barbaree, James M., January 2009 (has links)
Thesis (Ph. D.)--Auburn University. / Abstract. Includes bibliographical references (p. 129-151).
|
Page generated in 0.3767 seconds