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Mapping telomerase reverse transcriptase (hTERT) domains that contribute to tumorigenesisNimmo, Graeme A. M. January 2008 (has links)
Telomerase is a ribonucleoprotein that maintains telomere. It is activated in greater than 85% of human neoplasms. Traditionally, reactivation of telomerase during tumorigenesis was thought to be required solely to impart an indefinite lifespan. Recently, however, several studies have suggested that telomerase may contribute to tumorigenesis via an additional mechanism that is independent of its role in telomere lengthening. We sought to identify the region(s) of hTERT that contribute to this non-classical role of telomerase. We proposed to identify such regions by their ability to impart a tumorigenic phenotype in ALT cells transduced with activated Ras. Also, we attempted to develop methods to demonstrate that this role is not dependant of telomerase localizing to the telomere. The strategies employed and the progress gained toward each goal is presented in this thesis.
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Mechanisms of polyomavirus transformation of the mouse mammary gland /Webster, Marc A. January 1996 (has links)
Thesis (Ph.D.) -- McMaster University, 1997. / Includes bibliographical references (leaves 204-216). Also available via World Wide Web.
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Horizontal gene transfer by uptake of apoptotic bodies /Bergsmedh, Anna, January 2003 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.
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The role of sprouty-2 in the malignant transformation of human fibroblasts by HRAS oncogeneLito, Piro. January 2006 (has links)
Thesis (Ph. D.)--Michigan State University. Dept. of Biochemistry and Molecular Biology, 2006. / Title from PDF t.p. (viewed on Nov. 17, 2008) Includes bibliographical references. Also issued in print.
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Bmi-1 collaborates with H-ras to promote mammary epithelial cell transformation, tumorigenesis, and metastasisHoenerhoff, Mark James. January 2008 (has links)
Thesis (Ph.D.)--Michigan State University. Dept. of Pathobiology and Diagnostic Investigation, 2008. / Title from PDF t.p. (viewed on July 10, 2009) Includes bibliographical references (p. 157-174). Also issued in print.
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Bone morphogenetic proteins secreted by breast cancer cells upregulate bone sialoprotein expression in preosteoblast cells a thesis submitted in partial fulfillment ... for the degree of Master of Science ... /Bunyaratavej, Pintippa. January 2000 (has links)
Thesis (M.S.)--University of Michigan, 2000. / Includes bibliographical references.
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Immunotherapy of rat brain tumors with mutagen induced, cross-reactive tumor cell variantsSiesjö, Peter. January 1997 (has links)
Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted.
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Immunotherapy of rat brain tumors with mutagen induced, cross-reactive tumor cell variantsSiesjö, Peter. January 1997 (has links)
Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted.
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Cytogenetic and molecular alterations in immortalization of normal esophageal epithelial cellsZhang, Hao, January 2005 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2005. / Title proper from title frame. Also available in printed format.
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Transcriptional Alterations during Mammary Tumor Progression in Mice and HumansFancher, Karen January 2008 (has links) (PDF)
No description available.
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