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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
251

Mechanoregulation of chondrocytes and chondroprogenitors: the role of TGF-BETA and SMAD signaling

Mouw, Janna Kay 28 November 2005 (has links)
In pathological states such as osteoarthritis, the complex metabolic balance of cartilage is disrupted, leading to a loss in the integrity and biomechanical function of cartilage. Osteoarthritis affects more than 20 million Americans, costing the United States economy over $60 billion yearly. Risk factors for osteoarthritis include age, excessive joint loading, and joint injury. Tissue engineering offers a potential solution for the replacement of diseased and/or damaged cartilage. Unfortunately, plentiful donor cell populations are difficult to assemble, as chondrocytes have a well characterized lack of expansion potential. Mesenchymal progenitor cells offer an alternative with a high expansion potential capable of supplying large quantities of cells. Using an immature bovine model, the chondrogenic differentiation of articular chondrocytes and bone marrow stromal cells was found to be scaffold, media and mechanical stimulation dependent. TGF-beta signaling participated in the response of articular chondrocytes to dynamic compressive loading, as well as enhanced the chondrogenesis of bovine BMSCs, through interactions between loading and TGF-beta/Smad signaling. Also, dynamic loading altered gene expression, matrix synthesis rates and intracellular phosphorylation for bovine BMSCs. However the response of the cells to dynamic loading depends on both media supplementation and the duration of unloaded culture. These studies establish signaling through the TGF-beta pathway as a mechanotransduction pathway for chondrocytes and chondroprogenitors in 3D culture.
252

Regulation and role of catalases during development and oxidative stress in Dictyostelium discoideum /

Garcia, Maria Xenia U. January 2000 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2000. / Typescript. Vita. Includes bibliographical references (leaves 201-225). Also available on the Internet.
253

The role of inhibitors of differentiation (Id) and BMP/Smad signaling pathway in retinal cell development

Du, Yang, January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (p. 180-205). Also available in print.
254

The role of inhibitors of differentiation (Id) and BMP/Smad signaling pathway in retinal cell development /

Du, Yang, January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (p. 180-205). Also available online.
255

MCP-1 and APP involvement in glial differentiation and migration of neuroprogenitor cells

Vrotsos, Emmanuel George. January 2009 (has links)
Thesis (Ph.D.)--University of Central Florida, 2009. / Adviser: Kiminobu Sugaya. Includes bibliographical references (p. 45-50).
256

Regulation and role of catalases during development and oxidative stress in Dictyostelium discoideum

Garcia, Maria Xenia U. January 2000 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2000. / Typescript. Vita. Includes bibliographical references (leaves 201-225). Also available on the Internet.
257

Presenilin-1 and TCF/[beta]-catenin signaling : effects on neuronal differentiation /

Teo, Jia-Ling. January 2003 (has links)
Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 103-119).
258

Automatic white blood cell differentiation /

Park, Jaesang, January 2002 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2002. / Typescript. Vita. Includes bibliographical references (leaves 134-137). Also available on the Internet.
259

Automatic white blood cell differentiation

Park, Jaesang, January 2002 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2002. / Typescript. Vita. Includes bibliographical references (leaves 134-137). Also available on the Internet.
260

The role of inhibitors of differentiation (Id) and BMP/Smad signaling pathway in retinal cell development

Du, Yang, 杜洋 January 2009 (has links)
published_or_final_version / Anatomy / Doctoral / Doctor of Philosophy

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