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The role of the transcription factor LKLF in T cell quiescence /Buckley, Anne F. January 2001 (has links)
Thesis (Ph. D.)--University of Chicago, Committee on Immunology, August 2001. / Includes bibliographical references. Also available on the Internet.
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The roles of TCR, LFA-1 and CD28 in the function and organization of the immunological synapse /Sedwick, Caitlin E. January 2001 (has links)
Thesis (Ph. D.)--University of Chicago, Dept. of Neurobiology, Pharmacology and Physiology, August 2001. / Includes bibliographical references. Also available on the Internet.
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Analysis of the two domains of the response regulator, NarL, using nuclear magnetic resonance /Eldridge, Aimee Marie, January 2002 (has links)
Thesis (Ph. D.)--University of Oregon, 2002. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 102-106). Also available for download via the World Wide Web; free to University of Oregon users. Address: http://wwwlib.umi.com/cr/uoregon/fullcit?p3055686.
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Regulation of the metaphase-anaphase transition in mitosis in mammalian cells /Xu, Naihan. January 2003 (has links)
Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003. / Includes bibliographical references (leaves 242-266). Also available in electronic version. Access restricted to campus users.
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Signaling pathways and neuroprotection of retinal ganglion cells in a rat glaucoma model /Ji, Jianzhong. January 2002 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2002. / Includes bibliographical references (leaves 110-132).
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Single cell assays of exocytosis /Chen, Peng, January 2002 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2002. / Typescript. Vita. Includes bibliographical references (leaves 149-157). Also available on the Internet.
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Single cell assays of exocytosisChen, Peng, January 2002 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2002. / Typescript. Vita. Includes bibliographical references (leaves 149-157). Also available on the Internet.
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Regulation of mammalian STE20-like kinase (MST2) by phosphorylation/dephosphorylation, proteolysis and association with HSP90 during apoptosis /Deng, Yu. January 2003 (has links)
Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003. / Includes bibliographical references (leaves 148-164). Also available in electronic version. Access restricted to campus users.
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An exploration of the calcium signaling during somitogenesis in zebrafish (Danio rerio) /Leung, Fung Ping. January 2003 (has links)
Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003. / Includes bibliographical references (leaves 187-198). Also available in electronic version. Access restricted to campus users.
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The role of sonic hedgehog and bone morphogenetic proteins in the development of the vertebrate midbrainFogel, Jennifer Lynn, 1973- 08 October 2012 (has links)
During development of the nervous system, signals from specialized organizing centers generate distinct cell types. The signaling molecule, Sonic Hedgehog (SHH) is expressed by the floor plate (FP) and is sufficient to specify the ventral midbrain pattern. In the spinal cord, Bone Morphogenetic Proteins (BMPs) expressed in the roof plate (RP) specify dorsal cell-fates. The attenuation of BMP signaling is required for SHHmediated patterning of the ventral hindbrain and spinal cord, while BMP signaling is required in conjunction with SHH for ventral forebrain patterning. This thesis will focus on the function of SHH and BMPs in the midbrain by examining the molecules ability to pattern and regulate development. Midbrains of Shh[superscript -/-] mice were examined. Some ventral cell fates are specified in the Shh[superscript -/-] mouse in a Ptc1 and Gli1 independent manner. Ventral midbrain induction was observed to be Hh-independent by the existence of a Pax7-negative ventral midbrain territory before embryonic day 9. Interestingly, dorsal markers are not uniformly altered and increased cell death was seen in Shh[superscript -/-] dorsal midbrains. These results suggest specific regulation of dorsal patterning by Shh, rather than a simple deregulation. Several BMPs and their antagonists are expressed in a spatial and temporal manner in the midbrain. Expression of BMPs is seen in the RP, and rostral FP (rFP), which also expresses SHH. BMP signaling was manipulated using in vivo electroporation. NOGGIN misexpression resulted in a loss of RP and a reduction of dorsal cell-fates that was preceded by cell-shape changes, delamination of cells into the lumen and their elimination. This was accompanied by a reduction and alteration of midbrain size and shape. BMP blockade changed N-Cadherin distribution and perturbed pseudostratified morphology of the neurepithelium. Ventrally, BMP blockade resulted in a decrease of proliferation, while increasing differentiation, Notch signaling molecules at the rFP and medial FP markers. However ventral midbrain cell-fates were correctly specified. Notch-Delta signaling was examined in the Mib[superscript -/-] mouse. Different regulation of cell-fates was observed in the midbrain and spinal cord. Mib[superscript -/-] midbrains lacked a mature lateral FP, however ventral cell-fates are specified. Mib[superscript -/-] spinal cords lose Shh expression and several ventral cell-fates. / text
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