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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
101

The electrode-tissue interface during record and stimulation in the central nervous system

Lempka, Scott Francis January 2010 (has links)
Thesis (Ph. D.)--Case Western Reserve University, 2010. / [School of Medicine] Department of Biomedical Engineering. Includes bibliographical references.
102

Das hemmende Prinzip im Zentralnervensystem eine syndromgenetische Analyse /

Vieth, Jürgen. January 1970 (has links)
Thesis--Elangen-Nürnberg. / Copy imperfect: p. 128-129 wanting. Includes bibliographical references (p. [128]-146).
103

Studies on peripheral markers of central serotonergic activity and behaviour /

Kiive, Evelyn. January 2005 (has links) (PDF)
Thesis (doctoral)--University of Tartu, 2005. / Includes bibliographical references (p. 36-47).
104

Analysis of segmentation gene function and expression during arthropod CNS development /

Scheel, Molly Duman January 1999 (has links)
Thesis (Ph. D.)--University of Chicago, Dept. of Molecular Genetics and Cell Biology, August 1999. / Includes bibliographical references. Also available on the Internet
105

Different forms of modularity in trunk muscles in the rat revealed by various statistical methods /

Patil, Vidyaangi. Giszter, Simon Francis, January 2007 (has links)
Thesis (Ph. D.)--Drexel University, 2007. / Includes abstract and vita. Includes bibliographical references (leaves 125-129).
106

Experimental anatomical studies on the organization of the diencephalon

Sherlock, D. A. January 1982 (has links)
No description available.
107

Exploring molecular and cellular mechanisms underlying seizures in neurocysticercosis

de Lange, Anja 12 July 2021 (has links)
Neurocysticercosis is a disease in which larvae of the tapeworm, Taenia solium, infect the central nervous system of humans. Seizures are the most common symptom of NCC, occurring in between 70 % and 90 % of all symptomatic NCC cases. Neurocysticercosis impacts heavily on the quality of life of patients, and further presents a significant drain on the economic resources of endemic countries. Despite its considerable global impact, the molecular and cellular mechanisms underlying seizures in neurocysticercosis remain largely unknown. In this thesis I have explored novel models for neurocysticercosis by combining mouse hippocampal organotypic brain slice cultures with various preparations of a model parasite, Taenia crassiceps. Utilising these models, I first explored, using patch clamp and local field potential electrophysiology, how Taenia larval extracts directly affect neuronal excitability. I report that extracts of Taenia crassiceps resulted in a significant acute excitation of neurons and triggered seizure-like events in brain slices. Further investigation revealed that this excitation was mediated by the activation of glutamate receptors and that, indeed, the larvae of both Taenia crassiceps and Taenia solium contain and produce levels of glutamate sufficient to explain this effect. Chronic exposure of brain slices to intact, living, larvae did not, however, result in any changes in network excitability. Next, I investigate whether Taenia larvae produce acetylcholinesterases, as these enzymes have the potential to affect neuronal signaling by digesting the neurotransmitter acetylcholine. Ellman's assays, in situ acetylcholinesterase activity assays, and patch clamp electrophysiology reveal that both Taenia crassiceps and Taenia solium larvae produce acetylcholinesterases and that the activity of Taenia acetylcholinesterases is sufficient to digest acetylcholine at a concentration that alters neuronal signaling. Finally, I explore the effect that Taenia larval extracts have on the innate immune cells of the brain, as the responses of these cells can also alter neuronal excitability. Through the measurement of brain slice cytokine release using enzyme-linked immunosorbent assays, I discover that Taenia crassiceps extracts have robust antiinflammatory effects, which involve lipid, protein, and glycan elements. This thesis presents novel findings that reveal ways in which Taenia larvae interact with both neuronal and nonneuronal resident brain cells. It further delves into how these interactions could contribute to seizure generation in neurocysticercosis and proposes some potential new therapeutic approaches to treat seizures in neurocysticercosis.
108

Development of the medullary raphe nuclei of the rabbit: a midline dendrite bundle

Cummings, John P. January 1978 (has links)
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
109

Comparative study of CNS stimulatory activity and anorexigenic potency of phenylethylamine derivatives

Cox, Raymond H. January 1970 (has links)
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
110

Enzymatic reactions involving glycine within the central nervous system of the rat

Daly, Edward C. January 1979 (has links)
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

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