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Study of potential targets of miR-143 in cervical cancerWong, Ka-wing, 王家穎 January 2014 (has links)
Cervical cancer is a common gynaecological malignancy worldwide, with more than 450,000 incidences every year. Its etiology has been well documented to be associated with persistent infection with high-risk genotypes of human papillomavirus (HPV). The carcinoma can be screened by convention Pap smear and liquid-based cytology. Although preventable, cervical cancer remains a primary cause of death from cancer in developing countries where cytological screening is not so available. In the past decades, many studies have been carried out to explore molecular screening or diagnosis of cervical cancer, such as HPV DNA testing, histological or cytological biomarkers.
Micro RNAs, small non-coding RNA molecules of 18-25 nucleotides in length, areaberrantly expressed in various cancers. MiR-143 was reported consistently downregulated in cervical cancer tissues and cell lines, but its functional roles in cervical carcinogenesis has not been clearly illustrated.
Ten miR-143 downstream target genes were chosen and their expression levels in five cervical cancer cell lines (HeLa, SiHa, CaSki, C4-I and C33A) were investigated. In general, the gene expressions of candidates are upregulated in our cell lines with lowmiR-143 level. To further identify specific miR-143 targets in cervical cancer for biomarkers, protein expressions of TARDBP, ERK5, KRAS and PHF6were significantly downregulated upon miR-143 overexpression. Hence, miR-143 level is inversely correlated with the mRNA and protein expressions of these target genes.
Immunohistochemical study of ERK5 and TARDBP on FFPE samples including normal cervix, CINs and SCC cases showed that both ERK5 and TARDBP were positively stained in SCC samples, whereas weaker staining was found in CINs (both LSILs and HSILs) for both antigens. Thus, the intensity of positive staining ascended with the histological grading: LSIL, HSIL and SCC samples. Such differential expression pattern supports ERK5 and TARDBP as specific markers for high grade cancerous lesions.
In summary, two targets of miR-143, ERK5 and TARDBP, could be specific markers for high-grade lesion of cervical cancer. This is supported by their transcript and protein expressions inversely associated with miR-143 level, and that their strong immunohistochemical positivity in SCC samples. Their underlying molecular mechanisms involved in carcinogenesis and possible future applications require more in-depth researches. / published_or_final_version / Pathology / Master / Master of Medical Sciences
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Near real time confocal microscopy of Ex Vivo cervical tissue: detection of dysplasiaCollier, Thomas Glenn 28 August 2008 (has links)
Not available / text
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Autofluorescence and diffuse reflectance patterns in cervical spectroscopyMarín, Nena Maribel 28 August 2008 (has links)
Not available / text
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The biophysical origins of cervical tissue fluorescence and reflectance spectra : modeling, measurements, and clinical implicationsDrezek, Rebekah Anna 09 March 2011 (has links)
Not available / text
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The clinical significance of serum squamous cell carcinoma antigen (SCC) in carcinoma of cervix顔婉嫦, Ngan, Yuen-sheung, Hextan. January 1994 (has links)
published_or_final_version / Medicine / Master / Doctor of Medicine
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Studies on molecular mechanisms of transformation by human papillomavirus : the role of E6 and E5 oncogenesGu, Zhengming January 1996 (has links)
The ability of the HPV-18 E6 gene to impair p53-mediated transcriptional activity induced by DNA damaging agents was investigated. It is demonstrated that E6 can abolish DNA damage induced p53-mediated transcription and that a region from amino acid residue 113 to 117 of HPV-18 E6 protein was necessary for E6 to direct the degradation of p53. The biological importance of the E6/p53 interaction was then directly examined in HPV-16 containing cervical carcinoma derived cells by introducing the monomeric p53 mutant which is resistant to E6 mediated degradation. The two major observations made from this study were: (i) loss of p53 activity plays an important role in maintaining the malignant phenotype of these cells with respect to cell proliferation; (ii) the monomeric p53 mutant without its C-terminal regulatory region was biologically functional with respect to impairing cell proliferation in HPV-16 containing cervical carcinoma derived cells. Finally, it was revealed that the cellular MAP kinase signal transduction pathway was more active in cells expressing the HPV-16 E5 gene than in control cells or cells expressing E6 and E7. These observations help to define the mechanisms by which HPV oncogenes contribute to the development and maintenance of the neoplastic phenotype.
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Evaluating the perceptions and history of Papanicolaou smear screening among Mexican women in Ciudad Juárez, Chihuahua, MexicoHernández, Lorraine. January 2008 (has links)
Thesis (M.S.)--University of Texas at El Paso, 2008. / Title from title screen. Vita. CD-ROM. Includes bibliographical references. Also available online.
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The Psycho-social correlates of cervical cancer screening among young American Indian women /Solomon, Teshia G. Arambula, January 1998 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 1998. / Vita. Includes bibliographical references (leaves 235-250). Available also in a digital version from Dissertation Abstracts.
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Understanding the variations in fluorescence spectra of gynecologic tissueChang, Sung Keun. Richards-Kortum, Rebecca, January 2004 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2004. / Supervisor: Rebecca Richards-Kortum. Vita. Includes bibliographical references. Available also from UMI company.
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The clinical significance of serum squamous cell carcinoma antigen (SCC) in carcinoma of cervix /Ngan, Yuen-sheung, Hextan. January 1994 (has links)
Thesis (M.D.)--University of Hong Kong, 1995. / "September 1994." Includes bibliographical references.
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