It is well established that national retail chains impact small, single location retail businesses in terms of revenue generation, retail structure, retail type diversity, and location. This study examines the retail structure and diversity of five retail districts in the City of Denton, Texas. The analysis focuses on one central business district (CBD), one traditional retail strip center (University Drive, also known as US HWY 380), one special retail district (Fry Street District), one traditional enclosed shopping mall and associated development (Golden Triangle Mall), and one power retail center (Denton Crossing). The empirical foundation for the investigation is a historical business database covering years 1997 to 2010, obtained from Info Group's Reference USA. This Reference USA database includes location, industry, and status (single versus chain location) information for each business. Retail diversity and evenness were measured for each of the five retail districts using the Simpson's Diversity Index and the Simpsons Measure of Evenness, leading to specification of the differences that exist in retail structure and diversity among the districts. Golden Triangle Mall and Denton Crossing were primarily chain location in composition while Fry Street District, the CBD, and University Drive were primarily single location in composition. Across all years, the single versus chain status of the local business communities did not substantially change within any of the districts. The Fry Street District exhibited the most change in diversity as well as the lowest overall diversity among the retail districts, followed by University Drive and Golden Triangle Mall. The CBD did not experience any major change in retail type diversity. However, all retail districts experienced major changes in retail evenness. Overall for the city, single location retail businesses accounted for the majority of all the retail businesses, however, chain locations employed more people. In total, these findings indicate that the development of retail districts composed primarily of chain location retailer's affects retail district diversity and evenness but not retail structure.