The Irwin River catchment, located in the central western region of Western Australia, has been the scene of significant geomorphological change over both historical and geological timescales. This thesis focuses on the most recent of these changes, the anthropogenic imprint, through the development of a catchment-scale understanding of system behaviour. Analysis and modelling of changes in the hydrological behaviour of the system indicates that while the Irwin River has displayed a natural susceptibility to large flood events, these have been exacerbated by the widespread clearing of native vegetation throughout the catchment. As a result, when such events do occur, the catchment response is now larger, more direct and has a greater ability to cause erosion. However, the nature and detail of sediment yield processes and stream channel response varies markedly throughout the system. A series of representative channel reaches, as defined by their planform characteristics, geometry and architecture, are presented to illustrate spatial changes in stream channel behaviour. A distinct variation in river morphotypes is seen both downstream throughout the system as well as across the tributary sub-catchments of the Irwin River, Lockier River and Green Brook. This inter and intra sub-catchment variation in stream channel response can be attributed to changes in the boundary conditions and coupling mechanisms in operation throughout the Irwin River system. The pronounced spatial variability in response to human disturbance and the changing nature of catchment-scale connectivity seen in the Irwin River system differs markedly to that reported elsewhere in the literature. Appreciation of the variability in form, behaviour and evolutionary history throughout the Irwin River catchment not only provides the foundation for effective management but also contributes to a wider understanding of fluvial system behaviour. Unlike the majority of existing literature, which tends to identify and measure channel changes in a single catchment where historical variation to the sediment and discharge regime is well known, this study demonstrates the role of boundary conditions in determining the response of the fluvial system to changing environmental controls.