Thèse de doctorat : Lettres et Arts : Lyon 2 : 2000. / Thèse : 2000LYO20050. Titre provenant de l'écran-titre. Bibliogr.

Ph. D. Thesis--University of Wisconsin-Madison.

Thesis (Ph.D.)--Ohio University, June, 2005. / Includes bibliographical references (p. 213-225)

Thesis (Ph.D.)--Ohio University, June, 2005. / Title from PDF t.p. Includes bibliographical references (p. 213-225)

No description available.

No description available.

Amyloid proteins are found in all domains of life, and have a number of defining characteristics, including considerable β-sheet secondary structure and the ability to self-assemble into large, insoluble fibers. These insoluble aggregates are often deleterious to the cell, evidenced by amyloid proteins being involved in Alzheimer’s, Parkinson’s, and Huntington’s disease. Remarkably however, some organisms have found ways to circumvent the toxicity of amyloid proteins, and instead co-opt them as beneficial aspects of their development and survival. An example of this can be seen in the bacteria genus Streptomyces. Streptomyces bacteria have a complex, multicellular life cycle that involves progressing through a number of distinct developmental stages. The reproductive phase of the life cycle requires the activity of amyloid-forming proteins known as chaplins - hydrophobic proteins that polymerize on the cell surface, ultimately promoting reproductive development. Due to limitations in other model Streptomyces, key questions regarding the function of chaplins have not yet been addressed. The emerging model species Streptomyces venezuelae is unique given its rapid growth, its ability to develop in liquid, and its potential to adopt two distinct life cycle programs. This work sought to characterize how chaplins influence these processes. We created a number of chaplin mutants, and determined that chaplins contribute to these process in mostly redundant ways, but when deleted in bulk cause significant phenotypic changes. We have also shown that the requirement of chaplins in development goes beyond what was previously understood - as their loss affects development in all classical life cycle stages, and further impacts alternative life cycle programs. To understanding how chaplins are regulated in S. venezuelae, mutagenesis screens were conducted to identify mutants with altered chaplin regulation. These yielded promising candidates for further investigation. Collectively, this work has advanced our understanding of chaplin proteins, specifically how they are regulated, and how they affect various modes of Streptomyces growth and development. / Thesis / Master of Science (MSc)

Placing archetypal "underdogs" or "losers" in the roles of protagonists allows and encourages the viewer to identify with them or understand them as an idealized Other, though the audience may differ from the failure protagonist in social class, gender, or any other condition. In film, one of the most persuasive and ubiquitous media of the 20th century, underdog and weakling characters germinated in early popular comedies such as those by Charlie Chaplin and the other silent clowns. Using Chaplin's filmography to illustrate the underdog's ironic supremacy, this thesis aims to unravel the initial values and expectations inherent in Hollywood underdog comedy films, trace these components to their paradoxical political and economic roots, and draw conclusions on their social and economic consequences.

Thesis (M. Phil.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 96-99) Also available in print.

Submitted by Lucienne Costa (lucienneferreira@ufcg.edu.br) on 2018-07-02T19:49:21Z No. of bitstreams: 1 HALLYSON ALVES BEZERRA – DISSERTAÇÃO (PPGH) 2018.pdf: 5589915 bytes, checksum: 539dff2adbe56676e0ae48f95af6ee4a (MD5) / Made available in DSpace on 2018-07-02T19:49:21Z (GMT). No. of bitstreams: 1 HALLYSON ALVES BEZERRA – DISSERTAÇÃO (PPGH) 2018.pdf: 5589915 bytes, checksum: 539dff2adbe56676e0ae48f95af6ee4a (MD5) Previous issue date: 2018-03 / Capes / Charles Spencer Chaplin é um dos precursores da indústria cinematográfica hollywoodiana, deixando como legado, aproximadamente, oitenta filmes. Tendo sido um imigrante inglês nos Estados Unidos da América, deixou, ao longo da sua obra, várias narrativas construídas em cenários essencialmente urbanos. Na presente dissertação, intitulada “Luzes das Cidades Chaplinianas: As recepções das Urbs representadas na obra de Charles Chaplin (1914-1957)”, realizamos uma análise, a partir da relação Cinema-História, sobre como Charles Chaplin representou a cidade através do tempo, iniciando em suas primeiras produções de curtas-metragens até os filmes mais conhecidos, em longa metragem, como Luzes da Cidade e Tempos Modernos, evidenciando as suas práticas culturais, bem como as permanências e/ou mudanças durante o período em questão. Para tanto, a pesquisa fundamenta-se a partir da perspectiva da História Cultural, onde discutimos sobre a relação das obras chaplinianas, tendo como personagem central o homem andarilho (O Vagabundo) com as metrópoles urbanas do início do século XX. / Charles Spencer Chaplin is one of the forerunners of the Hollywood film industry, leaving behind as a legacy of nearly eighty films. Having been an English immigrant in the United States of America, he left, throughout his work, several narratives constructed in essentially urban scenarios. In the present dissertation entitled "Lights of the Chaplinian Cities: The Receptions of the Urbs represented in the work of Charles Chaplin (1914-1957)", we conducted an analysis, from the relation Cinema-History, on how Charles Chaplin represented the city through time , Starting in his first short film productions to the most well-known films, in feature films such as City Lights and Modern Times, showing his cultural practices, as well as the permanences and / or changes during the period in question. In order to do so, the research is based on the perspective of Cultural History, where we discuss about the relation of Chaplin's works, having as central personage the wanderer man with the urban metropolis of the early twentieth century.