In this work, a new electrochemical detection method was developed with the ability to determine a wide range of inorganic and organic species at, trace levels. In brief, the detection method takes advantage of all possible electrochemical reactions that may occur during scanning of the electrode potential. Changes in the detector response are mainly the result of inhibition of oxygen adsorption and hydrogen adsorption, alteration of electrical properties of the double layer, or redox processes of the adsorbate. Various electrochemical techniques were examined in the measurements; i.e. cyclic voltammetry, pulse amperometric detection, and square wave voltammetry. In those electrochemical techniques, the detection was carried out in a stripping mode after accumulation of analytes on the electrode surface. The smallest discernable signal is associated with about 0.1% surface coverage, which corresponds to the adsorption of about 10-18 mol of analyte on a ultramicroelectrode 5-[mu]m in radius. The response time of the detector to the concentration change in most cases is less than 1s. Electrochemical conditioning of the working electrode is sufficient to ensure a stable response for a period of several hours. It appears that square wave and cyclic voltammetry techniques are more suitable for the detection method. The linear dynamic range of the calibration curve depends on the characteristic of the analyte-electrode bond and redox processes of the analyte, which may occur at the electrode surface. For instance, for strongly adsorbing molecules the linear dynamic range extends over two orders of magnitude from about 10 -7 M to 10-5 M and for electroactive compounds from about 10-8 M to 10-4 M. In general, the relative standard deviation for replicate determinations was lower than 5%. Moreover, in these analyses, removal of oxygen from the analyzed solutions is not required.

Thesis (Ph. D.)--State University of New York at Binghamton, Chemistry Department, 2001. / Includes bibliographical references (leaves 209-237).

Thesis (Ph. D.)--York University, 1999. Graduate Programme in Chemistry. / Typescript. Includes bibliographical references (leaves 151-163). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pNQ39292.

Since the late 1990s our group has been working with groups in chemistry department at the University of Texas at Austin on a project referred as "Electronic Taste Chip," a MicroElectroMechanical System (MEMS) based miniaturized microfluidic chemical sensor with multianalyte detection capabilities. By integrating optical detection mechanism directly onto the silicon chip a cost effective, compact, and portable sensor can be realized enabling use of these chips out of conventional laboratory environment. Addition to the integration a noble approach of accessing a photodiode with non-contact powerless RFID type readout is presented. By doing so a packaged photodiode can be interrogated without direct electrical contact, enhancing the portability even further for a sensor operated in aqueous medium. First background information regarding the project as well as design and integration criteria is presented followed by demonstration of non-contact RFID-type readout of a photodiode. Detailed discussion on the development of process integration scheme is discussed along with the measurements verifying the performance of the fabricated photodiode. During this investigation normally overlooked design criteria of collection efficiency, the effect of how a target element is to be delivered to a detection mechanism on the overall performance of the sensor, is addressed and discussed.

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Thesis (Ph. D.)--University of Texas at Austin, 2007. / Vita. Includes bibliographical references.

Thesis (Ph. D.)--University of Nevada, Reno, 2006. / "May, 2006." Includes bibliographical references. Online version available on the World Wide Web.

Thesis (Ph.D.)--Tufts University, 1996. / Adviser: David R. Walt. Submitted to the Dept. of Chemistry. Includes bibliographical references. Access restricted to members of the Tufts University community. Also available via the World Wide Web;

Thesis (Ph.D.)--Tufts University, 1999. / Adviser: David R. Walt. Submitted to the Dept. of Chemistry. Includes bibliographical references (leaves 233-253). Access restricted to members of the Tufts University community. Also available via the World Wide Web;