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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-03-02T11:27:16Z No. of bitstreams: 1 mariacristinacardosodemendonca.pdf: 8315524 bytes, checksum: 5cb09e7f3009f401bfe32a402cc10858 (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-03-03T14:47:04Z (GMT) No. of bitstreams: 1 mariacristinacardosodemendonca.pdf: 8315524 bytes, checksum: 5cb09e7f3009f401bfe32a402cc10858 (MD5) / Made available in DSpace on 2016-03-03T14:47:04Z (GMT). No. of bitstreams: 1 mariacristinacardosodemendonca.pdf: 8315524 bytes, checksum: 5cb09e7f3009f401bfe32a402cc10858 (MD5) Previous issue date: 2013-08-26 / O peeling de fenol é considerado um importante agente no tratamento do rejuvenescimento facial, porém sua utilização implica em limitações pelo seu grande potencial de efeitos colaterais. Com o avançar de novas técnicas, houve a introdução dos lasers na propedêutica dermatológica, técnica essa mais segura, porém com limitações tanto no pós-operatório quanto no custo de cada tratamento. O presente trabalho propõe uma nova técnica de aplicação do peeling profundo para tratamento do fotoenvelhecimento com o objetivo de avaliar clínica e histopatologicamente a eficácia de uma nova forma de aplicação de fenol 88%, com padrão pontuado. O procedimento foi realizado em ambiente ambulatorial, em pacientes do sexo feminino sobre rugas estáticas e áreas de maior flacidez da face, visando o rejuvenescimento facial, com acompanhamento fotográfico e obtenção de amostras cutâneas para análise histopatológica antes e ao final do tratamento. Essa nova forma de aplicação reduziu consideravelmente o afastamento do paciente de suas atividades habituais, além do baixo custo em relação ao procedimento convencional. De acordo com os resultados, o fenol a 88% aplicado topicamente com técnica pontuada é efetivo no rejuvenescimento cutâneo. Assim, sugerimos que, a partir desta nova proposta, outros estudos sejam realizados para melhor elucidar os mecanismos de ação do fenol 88%, em grupos maiores de pacientes. / Phenol peeling is considered an important agent in the treatment of facial rejuvenation; however, its use carries limitations due to its high potential for side effects. With the advance of new techniques, lasers were introduced into the dermatological workup, a technique that is safer, but with limitations both in post-operative terms and in the cost of each treatment. This paper proposes a new deep peeling application technique for the treatment of photoaging, aiming to evaluate, clinically and histopathologically, the efficacy of a new way of applying 88% phenol, using a punctuated pattern. The procedure was performed in an outpatient setting, with female patients, on static wrinkles and high flaccidity areas of the face, aiming for facial rejuvenation. Accompanying photographs and skin samples were taken for histopathological analysis before and after treatment. This new form of application considerably reduced patients' withdrawal from their regular activities, and lowered the cost as well, compared to the conventional procedure. According to the results, 88% phenol applied topically using a punctuated technique is effective in skin rejuvenation. We thus suggest, based on this new proposal, that further studies be conducted to better elucidate the action mechanisms of 88% phenol in larger groups of patients.

Surfactant assisted solution exfoliation of expanded graphite by means of sonication was carried out in an attempt to produce non-covalent charge functionality on the surface of graphene for the directed self assembly of graphene films on patterned substrates via electrostatic interactions. This thesis includes the results of experimental research associated with: 1) quantifying the effectiveness of various di-functionalized dithienothiophene surfactant small molecules, 2) further understanding the surface affinity and interaction mechanism between these surfactant molecules and the surface of expanded graphite and graphene and 3) experimentally testing the feasibility of the directed self-assembly of graphene films by means of charge functionalization of graphene by the surfactant molecules adsorbed onto the surface of exfoliated graphene.