Diss. (sammanfattning) Linköping : Univ. / Härtill 6 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 6 uppsatser.

Salley in 1954, (122) was the first worker to use the hamster cheek pouch as a model for experimental carcinogenesis and to produce squamous cell carcinomas in this organ. For a number of reasons, the pouch is most suitable for sequential studies of carcinogenesis, and these include the fact that it is easily accessible and can be everted simply, facilitating macroscopic examination. Furthermore, its anatomic situation makes it a simple model for topical application of any carcinogen. Each animal has two pouches, thus providing its own control. In addition, the pouch serves as a storehouse and is lined only by stratified squamous epithelium with no glands or hair follicles in its wall, thus rendering it less susceptible to cyclic changes than more complex tissues, in which accessory structures are present.

Kan Ka-wing. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (p. [161]-[184]). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

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In vitro data from our laboratory demonstrate that vitamin B6 (B6) supplementation of estrogen receptor - positive and - negative breast cancer cells is growth inhibitory. Others have reported that dietary B6 supplementation resulted in increased fibrosarcoma pyridoxal phosphate (PLP) concentrations and a significant inverse relationship between tumor PLP concentration and tumor volume in mice. This suggests that, in contrast to data reported for normal cells, tumor cells are capable of accumulating supplemental B6. In the current study, we investigated the effects of dietary B6 supplementation on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats. Specifically, we aimed to identify the effect of pyridoxine (PN) supplementation on tumor growth and vitamin uptake by tumor cells. To accomplish this, 50 d old female Sprague Dawley rats were gavaged with 15 mg DMBA and fed a diet containing either 7, 350, or 1050 mg PN-HCl/kg diet, which is the equivalent of 1, 50, or 150x the National Research Council's B6 requirement for rats, respectively. These levels of PN have previously been shown to produce no overt signs of toxicity in rats. Throughout the experiment, the percent of rats with tumors and the average number of tumors per rat remained similar between groups. Mammary tumor growth rates were significantly increased in response to dietary B6 supplementation (P < 0.05). Liver PLP and pyridoxal (PL) concentrations did not differ between dietary treatment groups. Plasma PL and PLP concentrations were significantly higher in the group fed the 150x diet compared with the 1x diet (P < 0.001, P < 0.05). Mammary tissue PL concentrations of the 150x group were significantly higher (P < 0.05) than the 1x group, but no differences were observed in mammary PLP concentrations. Similarly to mammary tissue, no differences between groups were observed in tumor PLP concentration. However, tumor PL concentrations in both the 50x and 150x dietary treatment groups were significantly higher than those from the rats fed the 1x diet (P < 0.002). These data demonstrate that previously reported inhibitory effects of supplemental B6 on breast cancer growth in vitro do not occur in response to dietary supplementation at 50 or 150 times the B6 requirement in vivo. In fact, dietary B6 at 150x the requirement may actually promote mammary tumor growth. In light of these results, investigation of the effects of supplemental B6 on cancer growth in humans is warranted. Supported by American Cancer Society Grant # IRG-99-225-01. / Master of Science

by Chan Hiu Shuen. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (p. 123-135). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Lee Po Yuk. / Thesis (M.Ph.)--Chinese University of Hong Kong, 1987. / Bibliography: leaves 75-81.

Xu Feng. / Thesis (Ph.D.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (p. 205-233). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Lee Nga Lan. / Thesis submitted in: June 1997. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1998. / Includes bibliographical references. / Abstract also in Chinese. / Abstract --- p.i / Acknowledgment --- p.iii / Table of contents --- p.iv / List of tables --- p.viii / List of figures --- p.x / Glossary of abbreviations --- p.xi / Chapter CHAPTER 1. --- INTRODUCTION --- p.1 / Chapter CHAPTER 2. --- BACKGROUND --- p.3 / Chapter 2.1 --- OUTBREAKS OF SOLVENT INDUCED NEUROPATHY IN MAN --- p.3 / Chapter 2.2 --- WORLD-WIDE INVESTIGATIONS ON ORGANIC SOLVENTS HAZARDS --- p.5 / Chapter 2.3 --- HEALTH EEFECTS OF ORGANIC SOLVENTS --- p.8 / Chapter 2.3.1 --- Effects on the Nervous System --- p.9 / Chapter (a) --- Peripheral Nervous System / Chapter (b) --- Central Nervous System / Chapter 2.3.2 --- Other Effects --- p.13 / Chapter 2.4 --- METHODOLOGICAL ISSUES IN THE INVESTIGATION OF SOLVENT NEUROTOXICITY --- p.14 / Chapter 2.4.1 --- Study Design --- p.15 / Chapter 2.4.2 --- Exposure Measurements --- p.17 / Chapter 2.4.3 --- Outcome Effects Measurements --- p.18 / Chapter 2.5 --- UNSOLVED PROBLEMS IN THE STUDY OF SOLVENT NEUROTOXICITY --- p.20 / Chapter 2.6 --- ORGANIC SOLVENTS IN THE PRINTING INDUSTRY --- p.21 / Chapter 2.7 --- PRINTING METHODS --- p.25 / Chapter 2.8 --- OFFSET LITHOGRAPHY --- p.27 / Chapter 2.8.1 --- Principles of Offset Lithography --- p.28 / Chapter 2.8.2 --- Image Carriers for Offset Lithography --- p.29 / Chapter 2.8.3 --- Lithographic Presses --- p.32 / Chapter 2.8.4 --- Printing Process --- p.34 / Chapter CHAPTER 3. --- STUDY OBJECTIVES AND METHODS --- p.37 / Chapter 3.1 --- OBJECTIVES --- p.37 / Chapter 3.2 --- METHODS --- p.38 / Chapter 3.2.1 --- Study Population --- p.38 / Chapter 3.2.2 --- Visits --- p.41 / Chapter 3.2.3 --- Workers' Health Assessment --- p.42 / Chapter 3.2.4 --- Air Sampling --- p.44 / Chapter 3.2.5 --- Definition of Exposures --- p.48 / Chapter 3.3 --- DATA ANALYSIS --- p.49 / Chapter CHAPTER 4. --- RESULTS --- p.51 / Chapter 4.1 --- RESPONSE RATE --- p.51 / Chapter 4.2 --- CHARACTERISTICS OF THE STUDY POPULATION --- p.53 / Chapter 4.2.1 --- Printing Companies --- p.53 / Chapter 4.2.2 --- Study Subjects --- p.56 / Chapter 4.3 --- HEALTH PROBLEMS OF STUDY SUBJECTS --- p.60 / Chapter 4.3.1 --- Sick Leave --- p.60 / Chapter 4.3.2 --- Prevalence of Subjective Symptoms --- p.61 / Chapter 4.3.3 --- Mean Number of Symptoms --- p.64 / Chapter 4.4 --- AIR SAMPLING RESULTS --- p.66 / Chapter 4.4.1 --- Mean Concentration Levels of Solvents --- p.71 / Chapter 4.4.2 --- Mean Concentration Levels of Solvents by Printing Plants --- p.73 / Chapter 4.4.3 --- Mean Concentration Levels of Solvents by Locations --- p.75 / Chapter 4.5 --- EXPOSURE-RESPONSE RELATIONSHIPS BETWEEN ORGANIC SOLVENTS AND SYMPTOMS --- p.77 / Chapter 4.6 --- RISK FACTORS FOR SUBJECTIVE SYMPTOMS --- p.85 / Chapter CHAPTER 5. --- DISCUSSIONS --- p.90 / Chapter 5.1 --- RESPONSE RATE --- p.90 / Chapter 5.2 --- SOURCES OF BIAS --- p.91 / Chapter 5.3 --- STUDY SUBJECTS --- p.92 / Chapter 5.4 --- SOLVENT EXPOSURES --- p.93 / Chapter 5.4.1 --- Occupational Hygiene --- p.93 / Chapter 5.4.2 --- Exposure Classification --- p.95 / Chapter 5.4.3 --- Chemical Interaction --- p.98 / Chapter 5.5 --- HEALTH PROBLEMS --- p.99 / Chapter CHAPTER 6. --- CONCLUSION --- p.103 / REFERENCES --- p.105 / APPENDICES --- p.120 / Appendices A1 to A9: Newspaper reports on polyneuropathy induced by organic solvents in a Hong Kong printing factory --- p.120 / Appendix B: Telephone follow up form --- p.129 / Appendix C: Letter to the printing factory employer --- p.130 / Appendix D: Subjective symptom questionnaire for solvent workers --- p.131 / Appendix E: Questionnaire for exposed group workers --- p.132 / Appendix F: Questionnaire for non-exposed group workers --- p.140 / Appendix G: NIOSH Sampling and Analytical Method 1400 --- p.145 / Appendix H: NIOSH Sampling and Analytical Method 1500 --- p.150 / "Appendix I: Chemical Analytical Method from Department of Hygiene, School of Public Health, Sun Yat Sen University of Medical Sciences" --- p.157 / Appendix J: Air Sampling Worksheet --- p.159 / BIBLIOGRAPHY --- p.162