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Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafishKim, H.R., Santhakumar, K., Markham, E., Baldera, D., Greenald, D., Bryant, H.E., El-Khamisy, Sherif, van Eeden, F.J. 25 August 2020 (has links)
Yes / pVHL is a tumor suppressor. The lack of its function leads to various tumors, among which ccRCC (clear cell renal cell carcinoma) has the most serious outcome due to its resistance to chemotherapies and radiotherapies. Although HIF promotes the progression of ccRCC, the precise mechanism by which the loss of VHL leads to tumor initiation remains unclear. We exploited two zebrafish vhl mutants, vhl and vll, and Tg(phd3 / The work was supported by two BBSRC Grants: BB/R015457/1 and BB/M02332X/1.
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