Regression analysis is one of the most applied statistical techniques. The sta- tistical inference of a linear regression model with a monotone constraint had been discussed in early analysis. A natural question arises when it comes to the difference between the cases of with and without the constraint. Although the comparison be- tween confidence intervals of linear regression models with and without restriction for one predictor variable had been considered, this discussion for multiple regres- sion is required. In this thesis, I discuss the comparison of the confidence intervals between a multiple linear regression model with and without constraints.

Regression analyses constitutes an important part of the statistical inference and has great applications in many areas. In some applications, we strongly believe that the regression function changes monotonically with some or all of the predictor variables in a region of interest. Deriving analyses under such constraints will be an enormous task. In this work, the restricted prediction interval for the mean of the regression function is constructed when two predictors are present. I use a modified likelihood ratio test (LRT) to construct prediction intervals.

Regression analysis constitutes a large portion of the statistical repertoire in applications. In case where such analysis is used for exploratory purposes with no previous knowledge of the structure one would not wish to impose any constraints on the problem. But in many applications we are interested in a simple parametric model to describe the structure of a system with some prior knowledge of the structure. An important example of this occurs when the experimenter has the strong belief that the regression function changes monotonically in some or all of the predictor variables in a region of interest. The analyses needed for statistical inference under such constraints are nonstandard. The specific aim of this study is to introduce a technique which can be used for statistical inferences of a multivariate simple regression with some non-standard constraints.