Autism is one of the fastest growing childhood disorders in the world, and the families that have children with autism experience frustration and stress due to many practical problems. with the increase in the prevalence of autism, it is urgent to raise awareness of autism and to provide services and support for children with autism and their parents to improve the parent-child relationship and moderate the parental stress. with regard to families with children diagnosed as autistic, the purposes of this study are to: (a) examine the group differences in parental stress and parent-child relationship between Taiwan and the United States based on racial and cultural differences; (b) identify factors, if any, that influence the parental stress and parent-children relationship; (c) investigate if there are differences in the results of child development when children are diagnosed with autism in these two countries; (d) establish the Battelle Development Inventory-II in Mandarin Chinese version for use of evaluation with development delays in Taiwan. Findings revealed that: (a) the Battelle Developmental Inventory, Second Edition (BDI-II), is highly reliable with a great value of internal consistency in the use with parents and children with autism in Taiwan; (b) there is no significant difference in child development and parent-child relationship based on geographic region (Taiwan and the United States); (c) parents of children with autism in the United States overall have a more positive parent-child relationship and parenting attitude than parents of children with autism in Taiwan; (d) Children with autism who have a positive relationship with their parents have a higher pass rate on the evaluation of child development; (e) fathers reported higher pass rate on BDI-II than mothers in one of the standard deviations of over BDI-II performance; (f) parent-child relationships are positively correlated with parental stress; (g) parents who received services and support from a government agency or school in Taiwan have significantly lower scores on the parent-child relationship inventory; (h) fathers of children with autism have higher stress level than mothers; (i) parents who received services and support from parent groups (such as PTA or parent association) and from a government agency or school feel less stress than parents that did not receive those supports in Taiwan.