The main purpose of the study was to investigate whether illness-related factors predict marital adjustment in parents of children with cancer. The sample consisted of parents of hospitalized children, parents of children receiving outpatient treatment, and parents who brought their children for their routine controls ith a total of 105 mothers and fathers. The data were gathered by administering the Dyadic Adjustment Scale and Demographic, Illness- and Caregiver- Related Information form. Findings suggested that number of previous hospitalizations and support from spouse predict marital adjustment in parents of children with cancer. However, when the subscales were analyzed seperately, different predictors emerged. Number of previous hospitalizations predicted Dyadic Consensus, relapse and support from spouse predicted Dyadic Satisfaction, and currently receiving treatment and support from spouse predicted Dyadic Cohesion. No predictors for affectional Expression could be found. When only the parents of children currently receiving treatment are selected for analysis, the predictors do not change for Dyadic Satisfaction. However for Dyadic Cohesion, both parents as caregivers emerges as a predictor along with support from spouse. Single variables correlate significantly with the DAS Score, Dyadic Consensus and Affectional Expression. They are support from spouse for the DAS Score and Dyadic Consensus, and length of marriage for Affectional Expression.