This study was designed to assess the effect of chlorpromazine, a "tranquilizing" drug on Porteus Maze Performance, and to find whether such effect was permanent or transitory. The drug's effect on clinical behavior was also evaluated. Subjects were 44 adult, male, chronic psychotics from the Mental Hospital, British Columbia. Each pair was matched exactly on initial Maze scores and as closely as possible for age, hospital duration, education, occupation, and marital status. All subjects: had been diagnosed as schizophrenic; had not had chlorpromazine previously; had not been operated on psychosurgically; had been hospitalized for at least three years; showed no evidence of organic brain disease. Experimental subjects were selected by random method. The L-M Fergus Falls Behavior Rating Scale was used to evaluate clinical behavior. The experimental group received 300 mg. daily of chlorpromazine for 30 days, and the control group received 300 mg. daily of placebos for the same period. Maze scores and Behavior ratings were obtained for each subject before medication, during medication, and after medication. The results were treated statistically to find if there were any significant differences between the two groups. The conclusions were that chlorpromazine had no significant effect on either Maze performance or clinical behavior. The results were in the expected direction but the Maze decrement and the clinical Improvement attributable to chlorpromazine were too slight to have statistical significance. It was tentatively-concluded: 1. that Maze decrements resulting from chlorpromazine are transitory; 2. that a decline in clinical behavior shown by the control group was due to placebo effect; 3. that the maximum effects of chlorpromazine were not achieved due to the composition of the group, the moderate dose, and the short duration of treatment. / Arts, Faculty of / Psychology, Department of / Graduate

Thesis (Ph.D.)--Boston University. / The purpose of the present study was to explore the effects of a tranquilizing drug, chlorpromazine, on visual sensitivity and its modification in the presence of intersensory stimulation. The mutually recruitable neurone (MRN), a construct formulated in recent research on intersensory effects, provided a theoretical framework in which observed drug effects might be interpreted. Prior studies on intersensory effects have suggested that sensitivity in a primary sensory system first increases and then decreases as a function of the increasing intensity of the accessory stimulation, producing in turn both facilitation and inhibition. The literature on chlorpromazine has suggested that it might have effects on sensory processes but the magnitude and direction of these effects have varied with experimental conditions and there is need for further clarification. [truncated]

No description available.

Thesis (M.S.)--University of Michigan, 1958.

Thesis (M.S.)--University of Michigan, 1958.

Abstract In previous chlorpromazine pharmacokinetic studies a dramatic elevation in blood plasma levels of this drug was observed when taken in combination with oral contraceptives. Different mechanisms have been postulated to explain this observation. The aim of the study was to investigate whether oral contraceptives such as ethinyloestradiol and progesterone enhance the absorption of chlorpromazine by means of inhibiting P-glycoprotein (P-gp) and if this effect is mainly due to ethinyloestradiol or progesterone or their combination. The Caco-2 cell line was used as an in vitro model to study the effects of these compounds on the transport of chlorpromazine. Both apical to basolateral (AP-BL) and basolateral to apical (BL-AP) transport studies were done on chlorpromazine in combination with different compounds. Ethinyloestradiol enhanced the AP-BL cumulative transport of chlorpromazine by 11.5% compared to the control group, which was also statistically significantly higher than the effect caused by progesterone (0.8%). A combination of these two steroidal hormones enhanced the cumulative transport of chlorpromazine by only 2.0% compared to the control group. This indicates the possible existence of separate drugbinding sites for these two hormones and chlorpromazine on P-gp. The drug-binding site (or receptor) for progesterone probably interacts allosterically with the binding site for ethinyloestradiol and thereby decreasing its transport enhancing effects on chlorpromazine.

Thesis--M. Phil., University of Hong Kong, 1982.

published_or_final_version / Pharmacology / Master / Master of Philosophy

The cation radical of chlorpromazine in solution was studied in detail by electron spin resonance. The 16 line spectrum was interpreted in terms of a nitrogen atom, two equivalent protons at the first side chain carbon atom, and three almost equivalent protons from the ring system. The relative magnitudes of the splitting constants require many of the spectral lines to be coincident, and the result is the 16 line spectrum observed. Analysis of the splitting constants was done using Huckel molecular orbital calculations, from which it was deduced that the chlorpromazine cation structure is folded about the N-S axis, with an included angle of 104°. The spectral asymmetry observed in sulfuric acid solution was interpreted in terms of random molecular motions causing a fluctuating environment to arise at the nuclear positions. This leads to a modulation effect on the nuclear magnetic moment, and is responsible for linewidth variation. Further broadening due to exchange effects is discussed qualitatively. The asymmetry of the spectra enable the sign of the nitrogen splitting to be estimated -- it was found to be positive. A brief discussion of the electrical properties of chlorpromazine, using HMO calculations, was included, and some discussion of the mechanism of chlorpromazine drug action was also considered for completeness. / Science, Faculty of / Chemistry, Department of / Graduate

No description available.