Thesis (M. Phil.)--Chinese University of Hong Kong. / Bibliography: l. 88-97.

Thesis--University of Kentucky (Ph. D.), 2003. / Title from document title page. Document formatted into pages; contains vii, 65 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 60-65).

Gonadotropins were used to stimulate luteal function, as determined by progesterone secretion, in both in vitro and in vivo systems. LH and hCG were capable of significantly stimulating progesterone secretion in the in vivo systems. Stimulation of progesterone secretion by hCG was greater than that for LH. PMSG failed to increase progesterone production at any level of treatment. hCG was also used to stimulate progesterone production by the corpus luteum in mares during early gestation. hCG administration resulted in a significant (p < 0.10) increase in peripheral progesterone levels in treatment mares through day 14 post-estrus. Peripheral progesterone concentrations were also higher in hCG treated mares for days 15 through 30 post-estrus in mares that conceived. hCG treatment had no influence on anterior pituitary release of LH.

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on March 25, 2010). Vita. Thesis advisor: Michael Roberts. "December 2009" Includes bibliographical references

Graphene is essentially a monolayer of sp2 bonded carbon atoms, arranged in a honeycomb lattice. Graphene has in recent years attracted phenomenal interest from researchers in materials science, condensed matter physics, and electronics since its first demonstration in 2004. The importance of graphene research was epitomised by the Nobel prize for physics being awarded to pioneers of the field in 2010. The main topic of this research was the development of epitaxial graphene on silicon carbide (SiC) substrates. The substrate inferred processability of epitaxial graphene enables graphene devices to be fabricated on full wafers using standard semiconductor processing techniques. Biosensor research is a rapidly expanding field. The major driver comes from the healthcare industry but there are also applications for biosensors in the food quality appraisal and environmental monitoring industries. The key advantages of electrochemical biosensors over competing sensor technologies are the low cost of mass production, and ability to make sensors into small compact systems. Smaller, portable sensors allow for the development of point-ofcare medical devices, which can be crucial in fast diagnosis and long-term monitoring of diseases. Graphene channel resistor devices have been fabricated using electron beam lithography and a successfully developed contact metallisation scheme - using Titanium / Gold contacts. The metal-graphene contacts have been characterised using XPS and electrical current-voltage measurements. The graphene channel device has been used as the basis of an electrochemical sensor for human chorionic gonadotropin (hCG), an indicator of pregnancy - which has also been linked to increased risk of several cancers. The immunosensor developed is a promising tool for point-of-care detection of hCG, due to its excellent detection capability, simplicity of fabrication, low-cost, high sensitivity and selectivity.

No description available.

Bibliography: leaves 230-294. / xiii, 294 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Analyses in detail a native small fragment of hCG/[beta] hCG subunit, the [beta]-core hCG fragment which is found in large amounts in urine and may be of clinical importance. The aims were to purify the fragment, analyse its protein and carbohydrate structure, develop direct assay methods for its measurement, and to examine it's distribution in body fluids and it's relationship with the intact hCG molecule during pregnancy. / Thesis (Ph.D.)--University of Adelaide, Dept. of Obstetrics and Gynaecology, 1993

Human chorionic gonodotropin (HCG) affected in various ways cell cultures infected with strains of Rous sarcoma virus (RSV). The cell cultures studied were chick embryo fibroblasts (CEF), normal rat kidney cells infected with temperature-sensitive mutant (LA31-NRK) and a wild type RSV (B77-NRK). HCG increased the rate of transformation and viral titer of CEF cells infected with RSV, but not B77-NRK. HCG increased significantly transformation rates of LA31-NRK, only if the temperature sensitive transformation process was first delayed by incubation at non-permissive temperatures. It is suggested that some postinfective, pretransformational event(s) may operate before viralmediated transformation rates are increased by HCG.

The present investigation was designed to further our understanding of the interaction of pituitary (luteinizing hormone, LH) and placental (chorionic gonadotropin, CG) gonadotropins with the primate corpus luteum. Studies were performed (1) to characterize the LH/CG receptor population in the

RATIONALE OF THE STUDY. To carry out a retrospective chart review of all patients who had a peripartum hysterectomy in hospitals at different levels of health care in the Pietermaritzburg Hospital Complex to examine the incidence and indications for peripartum hysterectomy. METHODS. The charts of 120 cases of peripartum hysterectomy operations performed between January 2003 and January 2008 in the Pietermaritzburg hospital complex of University of KZN were analysed retrospectively. The total number of deliveries were 48 964. The traditional indications, risk factors and associated complications were revisited to determine if there have been changes in current obstetric practice. RESULTS. The overall incidence of peripartum hysterectomy at the Pietermaritzburg complex of hospital was 0.25/1000 deliveries (95% C1 0.2 – 2.9). Uterine atony, bleeding abruption placentae, placentae praevia, uterine rupture following induction and extension of uterine incision into the uterine arteries comprised 87.9% of the indications for peripartum hysterectomy. By far, the most common complications were wound infection and haemorrhage due to difficult haemostasis. Both comprised 61% of complications, others were bladder injury and renal failure. Coagulopathy occurred in 16.7% of cases of whom 2 died due to massive uncontrollable haemorrhage and 26.7% cases had relaparatomy. There were 13.3% of haemorrhagic shock and 5% developed septic shock. All the patients had blood transfusion, 13.3% of patients received platelets in addition to blood. The results showed that 55.8% had previous caesarean sections while 12.5% had VBAC. There were 75.8% live babies. CONCLUSION. The review noted that there has not been a significant change in the incidence and indications for peripartum hysterectomy. The incidence of peripartum hysterectomy in the study 0.25/1000 compared favourably with the findings from similar studies in different parts of the world. Worldwide the incidence of PH ranges from 0.2 to 5.09/1000 deliveries, in our study the incidence was 0.25/1000. / Thesis (M.Med.)-University of KwaZulu-Natal, Durban, 2012.