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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Influência da nicotina no foco de atenção : um modelo neurocomputacional para os circuitos da recompensa e tálamo-cortical / The influence of nicotine on attention focus : a neurocomputational model reward and thalamocortical circuits

Guimarães , Karine Damásio 30 March 2015 (has links)
Submitted by Maria Cristina (library@lncc.br) on 2015-10-08T14:40:37Z No. of bitstreams: 1 thesiskarine.pdf: 6490137 bytes, checksum: 5cfc4bafd419dffab8b58cc3783124ae (MD5) / Approved for entry into archive by Maria Cristina (library@lncc.br) on 2015-10-08T14:40:53Z (GMT) No. of bitstreams: 1 thesiskarine.pdf: 6490137 bytes, checksum: 5cfc4bafd419dffab8b58cc3783124ae (MD5) / Made available in DSpace on 2015-10-08T14:41:02Z (GMT). No. of bitstreams: 1 thesiskarine.pdf: 6490137 bytes, checksum: 5cfc4bafd419dffab8b58cc3783124ae (MD5) Previous issue date: 2015-03-30 / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / In this work we develop a neurocomputational model based on ordinary differential equations which describes the interaction between the reward circuit and the thalamocortical circuit, taking into account the influence of astrocyte. The physiology for these circuits is studied by a coupled model, used to obtain numerical results that describe the action potential behavior associated to each neuron in the neural network. The initial value equations of the proposed models are discretized using classical numerical methods. Thus, it is possible to study the attentional focus behavior when an exogenous substance is added to the system, in particular, to study the influence of nicotine on the attentional focus. The proposed modeling is applied on problems arising in medicine, specifically, in neuropsychiatry. The study cases refer to patients with chemical dependence in nicotine and attention deficit hyperactivity disorder (ADHD) / Neste trabalho desenvolvemos um modelo neurocomputacional baseado em equações diferenciais ordinárias, que descreve a interação entre o circuito da recompensa e o circuito tálamo-cortical, considerando a influência do astrócito. O estudo da fisiologia destes circuitos inspira a construção de um modelo acoplado para ser usado na obtenção de resultados numéricos que descrevem o comportamento do potencial de ação associado a cada neurônio da rede neural. Os problemas de valor inicial que representam os modelos estudados são discretizados usando métodos numéricos clássicos. Desta forma, é possível estudar o comportamento do foco de atenção quando uma substância exógena é adicionada ao sistema, em particular, estudar a influência da nicotina no foco de atenção. A modelagem aqui proposta é aplicada em problemas advindos da medicina, especificamente, da área de neuropsiquiatria. Os casos de estudos estudo estão restritos a pacientes com problemas de dependência química em nicotina e pacientes com transtorno de déficit de atenção e hiperatividade (TDAH).

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