Seven new steroids, GN70-153E (1), GN70-153F (2), GN70-153I (3), GN70-272F (4), GN70-272I (5), GN70-272L (6), and GN70-272L (7), were isolated from the Formosan soft coral Clavularia viridis by chromatographic separation of the EtOAc layer which was obstained from crude extraction in hexane¡ÐAcetone, 100% Acetone, Acetone¡ÐMeOH and 100% MeOH then partitioned between EtOAc and H2O. Their structures were determined based on the results of several kinds of spectroscopic analyses and HRESI-MS. Compounds 1-7 exhibited cyctotoxicity against HT-29 and P-388 cell lines in vitro.

Chromatographic separation of acetone/methylene chloride extracts of Formosan soft coral Capnella imbricata (GN75) led to the isolations of six new capnellenes, 8b,10a-diacetoxy-D9(12)-capnellene (1), D9(12)-capnellene-5b,8b,10a-triol (3), D9(12)-capnellene-8b,10a,13b-triol (4), 8b-acetoxy-D9(12) -capnellene (7), D9(12)-capnellene-8b,14b-diol (8), D9(10)-capnellene-12-ol-8-one (9), and three known compounds, D9(12)-capnellene-8b,10a-diol (2), D9(12)-capnellene-10a-ol-8-one (5), D9(12)-capnellene-8b-ol (6), one new calamenene, (+)-15-hydroxy-calamenene (10). One new prostanoid, GN61-97-11-8 (11) and five new steroids, GN61-91-141-14 (12), GN61-91-141-12 (13), GN61-77-6-I (14), GN61-77-6-E (15) and GN61-97-9-6 (16) were isolated from the methylene chloride extracts of the Formosan soft coral Clavularia viridis (GN61). All of these compounds were established on the basis of extensive spectral analysis and chemical reactions. The absolute structure of 2 was determined by MTPA esterifications. Compounds 1-3¡B5 and 12-16 showed more specific inhibition against the up-regulation of the pro-inflammatory iNOS and COX-2 proteins of LPS-stimulated RAW264.7 macrophage cells.