MENVSC (Climatology) / Department of Geography and Geo-Information Sciences / Subtropical anticyclones locate and modulate weather and climate over subtropical belts for both the Northern and Southern Hemispheres. This study investigates the spatio-temporal variability of the Mascarene High over the South Indian Ocean on (anomalous) weather and climate over southern Africa at intraseasonal, seasonal, interannual, multidecadal and event time-scales. The Mascarene High is located 25-35°S, 40-110°E, playing a vital role in day-to-day weather and climate patterns conditions over southern Africa. Spatio-temporal characteristics of the Mascarene High investigated in this study span the period 1985-2014 and 2071-2100, using NCEP-NCAR reanalysis datasets for present-day climate observations and the Conformal-Cubic Atmospheric Model (CCAM) for future projections. The Mascarene High is analysed using mean sea level pressure (MSLP) extracted from ECMWF ERA-interim monthly reanalysis data. The Mascarene High is also subjected to Principal Components Analysis, depicting eastern displacements of the weather system to be dominant for weather and climate fluctuations over southern Africa. The Mascarene High migrates south (north) during austral summer (winter) and is centred over the eastern Indian Ocean in summer in connection with the Indian Ocean Subtropical Dipole. Event scale analysis is also employed for investigating Mascarene High blocking and induced anomalous weather. Mascarene High blocking leads to anomalous rainfall events over southern Africa associated with tropical cyclones, cut-off lows and cloud bands. There is also a vital geographical variability of the Mascarene High development, distribution and movement in the South Indian Ocean at the different time-scales. Projections of the Mascarene High indicate a shift in mean location as a result of future expansion and intensification. This projected expansion and intensification is expected to shift tropical cyclone trajectories equatorward, with the baroclinic structure of cold fronts expected to shift poleward affecting changes in the weather and climate of southern Africa. This finding is important as it projects changes in weather and climate conditions over southern Africa in a changing climate due to increased greenhouse gas emissions.