This thesis provides a comparison between instance segmentation methods using point clouds and depth images. Specifically, their performance on cluttered scenes of irregular objects in an industrial environment is investigated. Recent work by Wang et al. [1] has suggested potential benefits of a point cloud representation when performing deep learning on data from 3D cameras. However, little work has been done to enable quantifiable comparisons between methods based on different representations, particularly on industrial data. Generating synthetic data provides accurate grayscale, depth map, and point cloud representations for a large number of scenes and can thus be used to compare methods regardless of datatype. The datasets in this work are created using a tool provided by SICK. They simulate postal packages on a conveyor belt scanned by a LiDAR, closely resembling a common industry application. Two datasets are generated. One dataset has low complexity, containing only boxes.The other has higher complexity, containing a combination of boxes and multiple types of irregularly shaped parcels. State-of-the-art instance segmentation methods are selected based on their performance on existing benchmarks. We chose PointGroup by Jiang et al. [2], which uses point clouds, and Mask R-CNN by He et al. [3], which uses images. The results support that there may be benefits of using a point cloud representation over depth images. PointGroup performs better in terms of the chosen metric on both datasets. On low complexity scenes, the inference times are similar between the two methods tested. However, on higher complexity scenes, MaskR-CNN is significantly faster.