Thesis (Ph. D.)--University of Texas, Austin, 2000. / Vita. Includes bibliographical references (leaves 159-173). Available also in a digital version from Dissertation Abstracts.

Thesis (Ph. D.)--University of Houston, 1967. / Degree granted by Dept. of Psychology. Bibliography: leaves [138]-148.

Thesis (M.A.)--York University, 2003. Graduate Programme in Psychology. / Typescript. Includes bibliographical references (leaves 51-57). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pMQ99351

Thesis (M. Med. Sc.)--University of Hong Kong, 2005.

Thesis (Ph.D.)--Ohio University, November, 2004. / Title from PDF t.p. Includes bibliographical references (p. 89-101)

Thesis (Ph. D.)--Virginia Commonwealth University, 2010. / Prepared for: Dept. of Psychology. Title from title-page of electronic thesis. Bibliography: leaves 170-201.

Research interest in cerebral small vessel disease, which is manifested as lacunar infarct and white matter changes, has surged in the last decade. Small vessel disease has been increasingly recognized via neuroimaging to be highly prevalent among the elderly and more importantly; it is associated with cognitive impairment. Since the population worldwide is ageing, the cognitive burden associated with small vessel disease is foreseen to rise. This burden will be particularly great in China where the population is vast. However, data of cognitive impairment related to small vessel disease among Chinese is scarce. / The methods and results of these studies will be presented in the thesis. In brief, the author concluded that (1) among Chinese stroke patients with relevant subcortical lacunar infarct, underlying intracranial large artery disease should be looked for before attributing that the lacunar infarct is due to small vessel disease because of its not uncommon association with lacunar infarcts among Chinese; (2) half of the patients with stroke associated with small vessel disease complain of varying severity levels of cognitive impairment 3 months poststroke and executive dysfunction also affects functional activities; (3) thalamic lacunar infarct and left frontal lobe atrophy have small yet significant influences on cognitive performances; (4) cerebral atrophy predicts prestroke cognitive impairment; and (5) Chinese frontal assessment battery is a moderately valid, while executive clock drawing test is not a valid test in the evaluation of executive dysfunction among Chinese with small vessel disease. / This thesis aimed to present studies that were conducted by the author among Chinese stroke patients on this particular field. The aims of the studies were to evaluate the (1) frequency of relevant intracranial large artery disease among Chinese stroke patients having subcortical lacunar infarcts; (2) frequency and impact of cognitive impairment after stroke associated with small vessel disease; (3) neuroimaging determinants of cognitive performances after stroke associated with small vessel disease; (4) determinants of prestroke cognitive impairment in stroke associated with small vessel disease; and the (5) validity of frontal assessment battery and executive clock drawing test in assessing executive dysfunction among Chinese patients with small vessel disease. / Mok Chung Tong Vincent. / "April 2005." / Adviser: Lawrence Ka Sing Wong. / Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3695. / Thesis (M.D.)--Chinese University of Hong Kong, 2005. / Includes bibliographical references (p. 180-197). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / School code: 1307.

Thesis (Ph.D.)--Virginia Commonwealth University, 2008. / Prepared for: Dept. of Anatomy & Neurobiology. Title from title-page of electronic thesis. Bibliography: leaves 155-194.

Thesis (PhD)--Stellenbosch University, 2015. / ENGLISH ABSTRACT: Abstract Neurocognitive deficits and thought disorder in schizophrenia have generally been accepted as core features of the illness, yet their underlying relationship, response to treatment, and correlations with outcome remain unclear. Most of the studies to date have used cross-sectional designs and focussed on stable patients already on treatment. The purpose of this study was to assess changes in neurocognition and thought disorder in antipsychotic naïve or minimally treated first episode psychosis (FEP) patients, over the course of 12 months of treatment according to a standard algorithm with flupenthixol decanoate (FD) long acting injectable antipsychotic. This was a prospective, non-comparative, open-label, longitudinal study of 42 patients with FEP. There was an initial wash-out phase of up to 7 days after which treatment was initiated with oral flupenthixol, 1 to 4 mg/day for 1 week prior to when the first long-acting FD was given. The starting dose of FD was 10mg every second week, with dose increases allowed at 6-week intervals. The Matrics Consensus Cognitive Battery (MCCB) and Rorschach Percerptual Thinking Index (PTI) were used as the primary co-measures for the assessment of neurocognition, thought disorder and perceptual disturbances respectively, at baseline prior to treatment, at month 6 and month 12. The main findings of this study were as follows: we confirmed the presence of significant neurocognitive impairment, thought disorder and perceptual disturbances prior to treatment, with improvement in neurocognitive performance and thought disorder from baseline to 6 months, with form perception improving later between month 6 and month 12. Improvements in symptoms were associated with improvements in neurocognitive performance, thought disorder and perceptual disturbances but a degree of residual impairment was evident at month 12. This study confirmed the association between neurocognition and form perception per se as well as their relative stability in FEP after initial improvement with treatment. We found support for the correlation between the amount of improvement in neurocognition, thought and perceptual disorder with outcome. We found the Social and Occupational Functioning Scale (SOFAS) to be a more robust measure of social and functional outcome with highest level of education (HLOE), substance abuse, reasoning-and-problem solving, form perception and Rorschach PTI emerging as predictors in a best subset regression analysis. The findings of this study suggest that neurocognitive impairments, thought disorder and perceptual disturbances have both state and trait like features, that patients benefit from treatment with a low-dose FGA, and that residual neurocognitive and perceptual impairment after treatment may indicate persisting underlying cerebral pathology. / AFRIKAANSE OPSOMMING: Abstrak Neurokognitiewe inkortinge en gedagteproses versteuring in skisofrenie word algemeen aanvaar as kern eienskappe van die siekte, tog is die onderliggende verhouding, die respons op behandeling, en die verwantskap met uitkoms onduidelik. Die meeste studies het 'n oorkruis-deursnee navorsingontwerp gebruik en gefokus op stabiele pasiёnte wat reeds op behandeling was. Die doel van hierdie studie was om die verandering in neurokognisie, gedagte vesteuring en perseptuele inkortinge te meet in eersteepisode psigose pasiёnte wat behandeling naïef was, of wat minimale behandeling gekry het, oor die verloop van 12 maande, met die toediening van 'n langwerkende, lae dosis flupenthixol inspuiting. Hierdie was 'n prospektiewe, nie-vergelykende, oop etiket, longitudinale studie van 42 eerste episode psigose pasiёnte almal op behandeling volgens 'n vaste protokol. Daar was 'n inisiёle uitwas periode van tot 7 dae waarna behandeling begin is op orale flupethixol, 1 tot 4 mg/dag vir 1 week voordat die eerste langwerkende flupenthixol inspuiting toegedien was. Die aanvangsdosis was 10mg elke tweede week met verhogings in dosis elke sesde week daarna. Die "Matrics Consensus Cognitive Battery'' (MCCB) en Rorschach "Perceptual Thinking Index" (PTI) is gebruik as die primêre instrumente vir die meting van neurokognisie, gedagte versteuring en perseptuele inkorting in noue samehang voor aanvang van behandeling, op maand 6 en op maand 12. Die hoof bevindinge van hierdie studie was as volg: Ons het die teenwoordigheid van beduidende neurokognitiewe, gedagte versteuring en perseptuele inkortinge bevestig voor behandeling, met verbetering in neurokognitiewe prestasie en gedagte versteuring tussen basislyn en maand 6, en verbetering in vorm persepsie wat later gevolg het tussen maand 6 en maand 12. Die verbetering in simptome was geassosieёr met verbetering in neurokognitiewe prestasie, gedagte versteuring en perseptuele inkortinge maar teen maand 12 was 'n graad van residuele neurokognitiewe en perseptuele inkortinge aanwesig. Hierdie studie het die verwantskap tussen neurokognisie en vorm persepsie bevestig, asook die relatiewe stabiliteit daarvan in eerste episode psigose na aanvanklike verbetering op behandeling. Ons het bewyse gevind wat die korrelasie tussen neurokognisie, gedagte en perseptuele versteuring met uitkomste ondersteun. Ons het bevind dat die "Social and Occuapational Functioning Scale" (SOFAS) 'n meer robuuste meting van sosiale en funksionele uitkoms is, en dat hoogste opvoedkundige vlak, substans misbruik, redenering-en-probleem oplossing, vorm persepsie en die Rorschach PTI as voorspellers identifiseer was in 'n beste substel regressie analise. Die bevindinge van hierdie studie suggereer dat neurokognitiewe, gedagte versteuringe en perseptuele inkortinge oor beide toestand en trek eienskappe beskik, en dat pasiёnte verbeter het met behandeling op 'n lae dosis eerste generasie antipsigotikum, en dat residuele neurokognitiewe en perseptuele inkortinge na behandeling aanduidend kan wees van onderliggende serebrale patologie.

published_or_final_version / Clinical Psychology / Doctoral / Doctor of Psychology