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The progression of CCI4-induced liver cirrhosis of rats and the protective effects of colchicine and green tea polyphenolsChung, Sau-yu, 鍾秀瑜 January 2001 (has links)
abstract / Medicine / Master / Master of Philosophy
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Effects of colchicine and endotoxin on bovine mammary involution and natural resistance to infection during the dry period /Oliver, Stephen Paul January 1980 (has links)
No description available.
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Effect of Colchicine on Neuronal ExcitabiltyOkafo, Ngozi 08 1900 (has links)
The abundance of microtubules in receptive dendrites suggests they may function in sensory transduction. Responses of frog muscle spindle receptors and joint receptors is inhibited within 25 minutes by 50 mM colchicine, a microtubuledisrupting agent. The inhibition is reversible upon removal of colchicine, and the time course of recovery is comparable to that of inhibition. Frog olfactory responses are briefly inhibited by washing the olfactory mucosa with perfusion fluid. Colchicine accentuates the inhibition and substantially retards the rate of recovery in a dose-dependent fashion. Colchicine does not affect axonal conduction, nor the oxygen uptake of isolated crab or frog leg nerves. The inhibitory action of colchicine is therefore an effect on the electrical excitability of the receptive dendrites or soma, and not an effect on axonal conduction.
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Colchicine Reversibly Inhibits Electrical Activity in Arthropod MechanoreceptorsReagan, Paul D. 08 1900 (has links)
Dendrites of cockroach tibial spine mechanoreceptors contain hundreds of free microtubules, which may have some relation to the generation of electrical activity. Deflection of a spine produces a train of action potentials. Continuous perfusion over a period of 4 hours results in no response decrement. Perfusion with 10mM colchicine reversibly inhibits the response within 5-7 minutes. Irreversible inhibition is produced by perfusion with 1mM vinblastine sulfate in perfusion solution containing 1% dimethyl sulfoxide. Deuterium oxide does not inhibit at concentrations less than 50%, nor does it counteract inhibition by 10mM colchicine. Colchicine may be affecting (1) intracellular microtubules, (2) membraneous tubulin, (3) other membrane components, or (4) axoplasmic transport of essential materials to the sensory dendrites.
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