<p>Due to the rapid development of nanophotonics, microring resonators suspended on a membrane holds promises for a scalable optical circuit with strong light-atom interaction. In this dissertation, I introduce a efficiently-coupled microring circuits for on-chip cavity QED with cold atoms and report my experimental efforts to integrate the optical chip into a ultrahigh-vacuum chamber with a magneto-optical trap for Rb atoms. My attempts to load single atoms into optical tweezers are also discussed.</p> <p>  </p> <p>  Although the loading of atom into optical tweezers above the top surface of resonator remains a challenge in experiment, I propose an alternative of cavity cooling based on cavity QED to facilitate the loading of atom into a two-color evanescent field trap around the waveguide. Assuming that the strong interaction between atoms and resonator modes is realized, I theoretically investigate the synthesis via photoassociation and the direct optical detection of a single ground-state cold molecule, whose corresponding excited-state has multiple decay channels. Similarly to the Purcell effect, the decay in a specific decay channel could be enhanced based on cavity QED, and therefore the synthesis efficiency can approach unity when the interaction between the resonator modes and a single cold molecule becomes stronger. In addition, for a single cold molecule without closed optical transition, the electromagnetically induced transparency is possible to be observed on our nanophotonic platform in the case of strong resonator-molecule coupling.</p>