This study explored the relationship between cultural mistrust level and attitudes toward seeking professional psychological help. It was hypothesized that Blacks with high levels of cultural mistrust, when compared to those with low levels, would show less favorable attitudes toward seeking formal help for psychological problems. Black students were administered the Cultural Mistrust Inventory, Help-Seeking Attitude Scale, Reid-Gundlach Social Service Satisfaction Scale, and Opinions About Mental Illness Scale. Using a 2 (gender) X 2 (mistrust level) MANCOVA, a main effect for the factor of mistrust level was found along with a mistrust level by gender interaction. Students with higher levels of cultural mistrust were found to hold less favorable attitudes toward seeking professional psychological help when compared to students with lower levels of cultural mistrust.