An experimental program was conducted to investigate some aspects of in-plane behaviour of masonry infilled steel frames. Eight concrete masonry infilled steel frames, consisting of three fully grouted and five partially grouted infills, were tested under combined lateral and axial loading. All specimens were constructed using one-third scale concrete masonry units. The in-plane lateral load was gradually increased at the frame top beam level until the failure of the specimen while an axial load was applied to the top beam and held constant. The parameters of the study included axial load, extent of grouting, opening, and aspect ratio of the infill. The experimental results were used, along with other test results from the literature, to evaluate the efficacy of stiffness and strength predictions by some theoretical methods with a focus on Canadian and American design codes. Cracking pattern, stiffness, failure mode, crack strength, and ultimate strength of the specimens were monitored and reported. Presence of axial load was found to increase the ultimate strength of the infilled frame but had no marked effect on its stiffness. Two specimens exhibited “splitting failure” due to axial load. Partially grouted specimens developed extensive diagonal cracking prior to failure whereas fully grouted specimens showed little or no cracking prior to failure. An increase in grouting increased the ultimate strength of the frame system but reduced its ductility. Presence of opening reduced the ultimate strength of the infilled frame and increased its ductility but its effect on the stiffness of the frame system was not significant. A review of current Canadian and American design codes showed that the Canadian code significantly overestimates the stiffness of infilled frames whereas the American code provides improved predictions for stiffness of these frame systems. Both design codes underestimate the strength of masonry infilled steel frames but grossly overestimate the strength of masonry infilled RC frames. / Masonry infilled steel frames tested under combined axial and lateral loading. Behaviour as affected by axial load, grouting, aspect ratio and openings discussed. Correlation between axial load level and the infill lateral resistance examined. Efficacy of the Canadian and American masonry standards on infill design was examined.