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The final report of the 77th Congress of the Humanities and Social Sciences conference. With overall attendance of 8,986 and 8,094 registered delegates, it was the largest conference in the University of British Columbia's and the Canadian Federation for the Humanities and Social Sciences' history.

Key photographs of the Congress 2008 conference held at the University of British Columbia were provided by Eugene Lin for UBC Public Affairs.

The CFHSS delegate's guide features local/UBC events and exhibits; panel discussions; association keynotes, joint sessions, and events; book fair and exhibitors' information; and, some of the many faces of Congress including those shown on page 46.

Thesis (M.S.)--Rochester Institute of Technology, 1993. / Typescript.

Thesis (Ph. D.)--Virginia Polytechnic Institute and State University, 1993. / Vita. Abstract. Includes bibliographical references (leaves 136-142). Also available via the Internet.

Six minor planets with mean motions approximately commensurable with that of Jupiter were observed photographically: (87) Sylvia, (107) Camilla, (414) Liriope, (909) Ulla and (1574) Meyer (all with ratio 9/5), and (334) Chicago (ratio 3/2). The plates were measured on a two-coordinate measuring-machine, and reduced by the method of plate constants. Orbits were derived for all except (1574) Meyer; for (334) Chicago and for (909) Ulla, two orbits were obtained for successive years, though in the former case the orbits were not accurate. The orbits of all six planets were also integrated numerically by computer, together with that of (153) Hilda, using a technique applied to the latter planet by J. Schubart. Based on the three-body problem, this applies three mutually-perpendicular components of the disturbing force to the orbital parameters, which consequently vary with time. Short-period variables are eliminated by averaging; only the longitudes of the two planets are allowed to vary, around one cycle of the commensurability. The derivatives of the orbital elements are calculated at intervals around the cycle, and their average values used in the integration. Schubart's original method neglects the orbital inclinations of both planets; this investigation extends the equations to include the inclinations. His results for (153) Hilda are reproduced, and shown not to change greatly whether the inclinations are included or omitted. For (909) Ulla, however, considerable differences are found. The results of the integrations on all seven orbits are presented in the form of graphs, covering time-intervals of 3000 years and more. The orbit of (909) Ulla was integrated twice, once taking the ratio of mean motions as 9/5, and again as 7/4. The integrations of (153) Hilda and (334) Chicago took the ratio as 3/2. All the orbits considered appear stable over long time-intervals. The perihelion advance of (334) Chicago is interrupted by long retrogressions, as noted by Schubart. The orbit of (909) Ulla shows similar, though less marked, behaviour. Both planets are somewhat removed from exact commensurability. Comparison was made between the orbits of four of the planets, derived from observations, and the orbits predicted by the numerical integrations. In most cases, the orbital parameters changed in the direction predicted but .to a greater degree, indicating that more variables affect the real orbits of the minor planets than are taken into account in this theoretical investigation.

Each year, between 300 and 500 million people develop malaria. Close to 3 million people die as a result. Due to resistance there are now few drugs left which are effective against malaria; one is a Chinese herbal remedy called qinghaosu (artemisinin). A section of this thesis represents an attempt to understand further the mode of action of this antimalarial agent. Several mechanisms involving iron have been proposed and the main categories reviewed (chapter 3). Techniques including ESR spectrometry, fluorescence and absorbance measurements were used to further probe the mode of action of qinghaosu. The findings of these studies provide support for a mechanism proposed by Wu et al., involving cleavage of the peroxy bridge in qinghaosu with the ferrous ion as opposed to antimalarial activity being due to the generation of high valent iron-oxo species. The ether derivative of qinghaosu, arteether has been studied using 2D NMR in order to provide further insight into the unusual structure of this compound (chapter 4). A comparison of the sp2 lactone functionality in qinghaosu with the sp3 ether group in arteether was performed. Evidence is presented for different conformations and chemical shift values. The immune system protects the human body from invasion by foreign substances or cells. A key part of this immune response comes from cellular components known as macrophages. The killing process of macrophages appears to involve nitric oxide. However, this natural defence mechanism is not very efficient as the body is susceptible to invasion by microbes. The term microbe includes both parasites and bacteria. The toxicity of nitric oxide (NO) and NO donor compounds has been investigated using the bacterium E. coli (chapter 5). In addition, studies have been performed using parasites. Malarial parasites (Plasmodia) are difficult to culture, therefore Leishmania parasites which cause the tropical disease leishmaniasis were used as a model (chapter 6). Evidence is presented for the toxic nature of NO donor compounds towards both parasites and bacteria. However, qinghaosu and its derivatives did not prove effective against Leishmania mexicana parasites in contrast with their reported antimalarial activity. The conclusions of this study suggest that qinghaosu possesses a toxicity mechanism selective for malarial parasites.

Edited by Alan Berg, Nevin S. Scrimshaw [and] David L. Call. / Includes bibliographical references.

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