The purpose of this cross-sectional and exploratory study was to describe an interaction model of parental and adolescent attributes and sexual communication influences on intentions for contraception and condom use in Mexican high school students between 14 and 17 years of age. This study utilized a secondary analysis of data from an existing experimental study. Concepts from the Theory of Planned Behavior, the Social Cognitive Theory, and the Ecodevelopmental Theory provided the contexts with which to guide this study. The study sample consisted of 756 adolescents and their parents. A SEM model building approach was used to guide the analyses. The model fit indices suggested that the sample data did not have an acceptable fit to the combined measurement model (X²[subscript (30)] = 92.215, p = 0.0000, CFI = 0.97, TLI = 0.95, RMSEA = 0.05, SRMR= 0.04). Based on the correlation coefficients, the observed variables of parents' and adolescents' familialism and religiosity and adolescents' intentions for contraception and condom use were excluded from the structural equation modeling analyses. Two alternative models were constructed form the original and both had an acceptable fit, but based on the theoretical background, one was selected (X²[subscript (15)] = 27.289, p = .0265, CFI = .99, TLI = .99, RMSEA = .03, SRMR = .02). The revised model parents' attributes (self-efficacy for sex communication and beliefs toward sex) showed a strong relationship (r = 0.80) with parents' sexual communication (communication about sex and comfort with sex communication). An additional moderately strong correlation was found between adolescents' sexual communication (communication about sex and comfort with sex communication) and parents' sexual communication (r = .31). Although the final model in this study did not explain the direct and mediator effects on adolescents' intentions for contraception and condom use, findings add new information in relation to the phenomenon of parent-adolescent communication about sex in Mexico. Several conclusions were also drawn from the relationships among parents' attributes, adolescents' attributes, parents' sexual communication, adolescents' sexual communication, and adolescents' intentions for contraception and condom use. Findings from this study are congruent with similar research and can be useful in developing intervention programs to prevent HIV/AIDS in Mexican adolescents.