Proefschrift--Utrecht. / "Stellingen": 1 leaf laid in.

Thesis (M.S.)--University of Wisconsin--Madison, 1969. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

No description available.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1970. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliography.

Thesis (M.D.)--University of Maryland. / Microform version available in the Readex Early American Imprints series.

Thesis (M.S.)--University of Wisconsin--Madison, 1968. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

The precise neuroanatomical pathways underlying seizure genesis and propagation are largely unknown. Current evidence suggests that epileptiform activity may travel along preferred anatomical routes and that some structures may act as “gates” that funnel and spread seizure activity throughout the brain. Burchfiel and Applegate (1989a) have proposed a gating hypothesis to explain kindled seizure propagation. According to this hypothesis, kindling involves three distinct phases that are separated by two crucial gates. The first gate mediates the expression of partial seizures, and the second gate mediates the expression of fully generalized seizures. Little work has been done in determining which anatomical sites contain these gates, in particular the second gate. The following experiments set out to investigate the role that the claustrum may play in mediating the second gate, responsible for the expression of kindled generalized seizures. Experiments 1 and 2 utilized correlative strategies to address the claustrum's participation in kindling. In Experiment 1, kindling was evoked directly from claustrum and these properties were compared with the nearby structures of the amygdala, insular cortex, and perirhinal cortex. The claustrum generally exhibited much more potent epileptogenic attributes than the other structures, including quick progression to seizure generalization and more vigorous and sustained convulsions. However, the claustrum, shared many electrographic and convulsive properties with the insular and perirhinal cortices, including a two phase development of generalized seizures, rapid progression to seizure generalization, and quick onset to limb convulsions. In Experiment 2, further dissociations were detected between claustrum and amygdaloid kindling by changes in molecular products linked with neural plasticity. Claustrum kindling was associated with generally more intensive expression of claustrum in kindling. Experiments 3 and 4 used more direct approaches to address the role of the claustrum in kindling. In Experiment 3, alternating stimulation between the claustrum and amygdala demonstrated that the claustrum was capable of arresting amygdaloid kindling at the partial seizure stages. This kindling antagonism effect was not observed with stimulation of the superficial insular cortex, perirhinal cortex, or piriform cortex. In Experiment 4, lesions applied to the claustrum were effective in delaying, but not blocking amygdaloid kindling. These delays were in amygdaloid kindling were produced by small lesions restricted to the ipsilateral anterior claustrum. Taken together these data suggest that the claustrum may represent the crucial mediator of the second gate responsible for kindled seizure generalization. / Graduate

Differentiating between organic epilepsy and psychogenic pseudoseizures is a difficult task even for experienced practitioners . Both disorders present in a similar manner and at present there are no clinical signs that distinguish between them. Latrogenesis may occur when psychogenic seizures are treated medically and sometimes aggressively in order to control seizure activity. Quality of life is negatively impacted on in both patient groups and stigmatisation and social isolation frequently occur. Psychiatric comorbidity is associated with both epilepsy and psychogenic seizures. The primary aim of this study was to explore the possibility of finding a definitive means of discriminating between the two patient groups. This study assessed quality of life and psychiatric dysfunction in both patient groups using the QOLIE-31 and the SCL-90-R instruments, respectively. The Seizure Questionnaire was used to assess qualitative aspects. The sample (n = 19) was made up of 10 females and nine males with a mean age of 30.6 years (S D = 8.9, range l8 - 44 years). One case of mixed seizures was excluded. The sample was taken from an epilepsy monitoring unit in a hospital in Durban, South Africa. On the scales of the SCL-90-R, Anxiety showed significant difference between groups and on the QOLIE-31 scales, Energy/Fatigue, Cognitive Functioning and Overall score showed significant differences. These differences were in the expected direction as found in previous research i n the literature. These trends need to be interpreted cautiously given the sample size. / Thesis (M.Soc.Sc.)-University of KwaZulu-Natal, 2006.

Thesis (M.S.)--Ball State University, 2009. / Title from PDF t.p. (viewed on June 07, 2010). Includes bibliographical references (p. 75-77).

Thesis (Ph. D.)--Columbia University, 1935. / Vita on slip mounted on verso of last leaf. Concerning the relation of ketosis, produced by diet, inanition or injection, to convulsions of experimental origin in cats, with a brief reveiw of the literature pertaining to the problems of ketogenic diet and fasting in the treatment of epilepsy. cf. Introd. and scope. "Read at the nineteenth annual meeting of the American pshchiatric association, Section on convulsive disorders, New York, N.Y., May 28-June 1, 1934." Bibliography: p. 46-47.