Thesis--Wisconsin. / Vita. Includes bibliographical references (leaves 111-117).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1974. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (M.S. Ed.)--Virginia Polytechnic Institute and State University, 1993. / Vita. Abstract. Includes bibliographical references (leaves 51-54). Also available via the Internet.

Thesis (M.S. Ed.)--Virginia Polytechnic Institute and State University, 1994. / Vita. Abstract. Includes bibliographical references (leaves 69-71). Also available via the Internet.

Thesis (Ph.D.)--Victoria University (Melbourne, Vic.), 2009.

Objective: To examine the effect of exercise-based cardiac rehabilitation program for secondary prevention of coronary heart disease on cardiac-related mortality, recurrent cardiovascular event and quality of life. Methods: All studies published between 1990 and 2013 in PubMed, and from 1980 to 2013 in EMBASE, which evaluated the effectiveness of exercise-based cardiac rehabilitation program for coronary heart disease. Using the specific keywords “Cardiac rehabilitation”, “Coronary heart disease” OR “Ischemic heart disease” [MeSH], “Exercise” OR “Physical activities” AND “Quality of life” OR “Mortality” AND Cardiovascular events” were searched. A total of 7randomized controlled trials out of 5,051articles from PubMed and 117 articles from EMBASE were included in this systematic review. The primary outcome measures used in the included seven studies were HRQOL, restenosis, cardiac event, cardiac related mortality. Similar demographic and clinical characteristics of the subjects between the intervention and the control groups were recorded. The studies were from five countries. The average age of the subjects in the seven studies was 61years, the average half of them have history of myocardial infarction. Though there were discrepancies among the results generated in the included studies, the potential benefits of exercise-based cardiac rehabilitation could be seen. Results: Compared with the non-exercise-based cardiac rehabilitation, patients allocated to the exercise-based cardiac rehabilitation program had greater improvement in HRQOL and reduction of cardiac events. The result of reducing restenosis was inconsistent. The cardiac related mortality is not significant difference between exercise-based and non-exercise-based cardiac rehabilitation. / published_or_final_version / Public Health / Master / Master of Public Health

M.A. / Chronic degenerative disease is responsible for a high percentage of deaths in industrialised westernised communities. These findings are not surprising if viewed in the light that most people consider physical activity not to be a priority in their daily activities. During the last decade, it would seem that employers have realised that the health status of an employee can have a direct influence on productivity, efficiency and absenteeism in the working environment. In an attempt to lower health-related costs, reduce absenteeism and improve productivity, some employers have started implementing a variation of total wellbeing and workers’ support programmes as part of their employee assistance programmes. A pressing question is, however, how effective these wellness programmes are. In order to evaluate the effect of such a programme, the present study used a sample of 76 employees in middle- to top management at a big corporate company. During 2002, tests were performed on twelve CAD risk factors, after which an intervention programme was introduced. Twelve months later (2003), the first intermediate test was conducted, using the same protocol. The second intermediate test followed in 2004, duplicating the procedures. The post-test and data analysing were conducted four years after the first evaluations. Subjects were monitored for changes in: total cholesterol, HDL-cholesterol, LDLcholesterol, triglycerides, TC/HDL ratio, LDL/HDL ratio, fasting blood glucose, systolic blood pressure, diastolic blood pressure, body mass index, waist-to-hipratio and waist circumference. The Repeated Measures General Linear Model Test was used to determine significance (P ≤ 0.05) from pre- to post-test. A novel CAD risk score was also iv developed from peer-reviewed literature by considering each of the 12 CAD risk factors measured. The results demonstrated that the wellness programme decreased CAD risk by 26% amongst the 76 participants in this study. The TC, LDL-C, LDL/HDL-C ratio, TC/HDL-C ratio, fasting blood glucose, resting systolic blood pressure, resting diastolic blood pressure and waist-to-hip ratio improved significantly, while triglycerides showed a non-significant improvement. The three CAD risk factors that deteriorated significantly during the study period were high-density lipoprotein cholesterol, BMI and waist circumference. The major finding of this investigation thus suggests that a corporate wellness programme has long-term beneficial effects on CAD risk and that the reduction in CAD risk is mainly attributed to the beneficial effects of regular exercise.

The purpose of this study was to test the hypothesis that arbutamine, a specific B₁-adrenergic agonist, will not cause different circulatory and physiologic effects than the less specific endogenous catecholamines released in response to an exercise stress test in persons with known or suspected coronary artery disease. Nine male subjects, mean age 66 years, completed symptom-limited arbutamine (ESA) and exercise (ETT) stress tests in a randomized cross-over study. The ESA delivery device controlled infusion rate to induce a graded heart rate increase of 8 bt min⁻¹. Heart rate, systolic blood pressure, diastolic blood pressure, rate pressure product, ST segment shift, and specimens for epinephrine, norepinephrine, dopamine, cortisol, insulin, glucagon, glucose, free fatty acids, glycerol, and lactate were collected at baseline, immediate post-stress, and 10, 30, and 60 minutes post-stress. The research hypothesis was rejected. Repeated measures analysis of variance for each measure demonstrated a significant (p ≤ .05) time treatment interaction in heart rate, systolic blood pressure, rate pressure product, insulin, glucagon, glycerol, free fatty acid, and lactate responses and a significant time effect for cortisol response. Circulatory differences included higher systolic blood pressure and rate pressure product responses for ETT than ESA and a more rapid recovery of circulatory variables following ETT. Metabolic differences were due to higher free fatty acid and glycerol responses for ESA than ETT and a slower recovery of these metabolites and lactate following ESA. Hormonal differences included an earlier and greater magnitude rise in insulin response for ESA than ETT. There were no differences (p ≤ .05) by treatment, time, or time treatment interaction for diastolic blood pressure, ST segment shift, catecholamines, or glucose. In conclusion, arbutamine caused different circulatory and physiologic effects consistent with differences in adrenergic receptor activity. Arbutamine caused substantial B₁₊₂ agonist effects on hormonal and metabolic responses in cardiotonic doses employed clinically for diagnostic stress testing and may impact clinical interpretation of stress test results. / Ph. D.

D.Phil. (Biokinetics) / Please refer to full text to view abstract