Thesis (MHSc--Health Science) -- Auckland University of Technology, 2005. / Also held in print (145 leaves, 30 cm.) in Akoranga Theses Collection (T 616.0250231 GAB)

Background: Critically ill abdominal surgery patients are at risk of developing a paralytic ileus. Multidisciplinary interventions aim to prevent post-operative complications in the intensive care unit; including interventions to prevent the development of a paralytic ileus. However, the implementation of preventative interventions occurs ad hoc and these high risk patients still develop a post-operative paralytic ileus. Aim: The aim of the study was to explore the implementation of post-operative interventions used in the critical care unit to prevent a paralytic ileus in patients following major open abdominal surgery. Research design and methods: A quantitative, exploratory retrospective research design was used to answer the research question. Patient medical records were retrieved from a specialised intensive care unit situated in a private hospital in Gauteng. A unit of analysis represented the study population and a sample frame was used for choosing patient medical files in the study. Data was collected using a data collection sheet developed from literature. Data was analysed using descriptive statistics (frequency tables, odds ratio, relative risks, Pearson Chi-square test and Fisher’s exact test). Results and Conclusions: After data analysis, the results of the study were documented. Conclusions deducted from this study highlighted three significant interventions associated with the incidence of a post-operative paralytic ileus. Further research on these three interventions may possibly prevent a paralytic ileus in critically ill abdominal surgery patients in the future. Implementation of specific evidence-based post-operative interventions has been recommended to critical care providers of the private hospital group. / Dissertation (MCur)--University of Pretoria, 2020. / Nursing Science / MCur (Nursing Sciences) / Unrestricted

Background: Acute kidney injury occurs in one out of ten cardiac surgery patients. Cardiac surgery-associated acute kidney injury not only increases patients’ mortality rate but the length of stay in intensive care unit and hospital. Cardiac surgery patients’ long- term risk for chronic kidney disease and heart failure increases with the incidence of acute kidney injury. Various preoperative, intraoperative and postoperative risk factors are associated with the development of cardiac surgery-associated acute kidney injury. Aim: The aim of the study was to identify the risk factors associated with acute kidney injury in patients who underwent cardiac surgery. The identified risk factors were categorized into modifiable, partially modifiable and non-modifiable risks. The frequency of acute kidney injury among cardiac surgery patients was also assessed. Research design: The researcher chose a quantitative correlational retrospective design and conducted a retrospective chart review to assess the risk factors associated with AKI in patients that had undergone cardiac surgery. Methods: Non-probability purposive sampling was used to select the records of patients that underwent cardiac surgery between January 2014 and December 2018. Data collection was done using a self-developed audit tool. Descriptive and inferential statistics were used for data analysis. Significance: The study enabled the researcher to identify and categorize the risk factors into modifiable, partially modifiable and non-modifiable categories. Early recognition and mitigation of risk factors could prevent patients from developing cardiac surgery- associated acute kidney injury. Research findings: The study found a 22.7% frequency of CSA-AKI. Anaemia, hypoalbuminemia, hyperglycaemia, use of N-acetylcysteine and fluid overload were identified as modifiable risk factors. Bicarbonate level <22mmol/L, use of diuretics, use of antibiotics, longer duration of surgery, fresh frozen plasma use >500ml on the day of surgery, red blood cell transfusion >1L on the day of surgery and prolonged use of mechanical ventilation were partially modifiable risk factors. No non-modifiable risk factors were identified. Keywords: Cardiac surgery-associated acute kidney injury; risk factors; modifiable, partially modifiable and non-modifiable. / Dissertation (MCur (Critical Care Nursing))--University of Pretoria, 2020. / Nursing Science / MCur (Critical Care Nursing) / Unrestricted

Includes abstract. Includes bibliographical references.

Includes bibliographical references / Objective: To describe the characteristics and outcomes of children admitted to PICU following cardiac arrest between January 2010 and December 2011. Methods: Retrospective descriptive study of routinely collected data. Results: Of 2501 PICU admissions, 110 (4.4%; 58.7% male) had preceding cardiac arrest, 80.6% of which occurred in hospital. Median (IQR) age was 7.2 (2.5 - 21.6) months; 30.8% had chronic underlying disease. Children presented most commonly with respiratory (n=28, 27.2%), cardiovascular (n= 22, 21.4%), and gastrointestinal disease (n= 20, 19.4%). Twenty-eight (27.2%) arrested while undergoing a procedure. Cardiopulmonary resuscitation (CPR) was given for median (IQR) 10 (5 - 20) minutes. Thirty-five (34%) patients received no adrenaline, 44 (42.7%) received up to 3 doses of adrenaline, and 24 (23.3%) received more than 3 doses of adrenaline during resuscitation. Duration of CPR and number of adrenaline doses did not significantly influence patient outcome. Survival to PICU discharge was 63 (61.2%), 57 (55.3%) survived to hospital discharge with half the deaths in PICU occurred within 24 hours of PICU admission. Out of 51 survivors whose neurological status were assessed 32 were normal, 6 had mild disability, 7 had moderate disability and 6 had severe disability. Standardized mortality ratio (actual/mean predicted) was 0.7. The median (IQR) length of stay in PICU and hospital were 3 (1 - 8) and 27 (9 -52) days respectively. Pediatric risk of mortality (PIM2) score was the only variable independently associated with mortality on multiple logistic regression (adjusted OR 1.05; 95% CI 1.02 - 1.07; p=0.0009).

Objective- We aimed to describe the use of blood products following cardiac surgery, as well as the outcomes and factors associated with post-operative blood product use Design- Prospective, single centre observational study Setting- Paediatric intensive care unit (PICU) in Cape Town, South Africa Patients- One hundred and twenty-six children <18 years old admitted to the PICU following cardiac surgery between July 2017 and January 2018 Interventions- None Measurements and Main Results- The data was prospectively obtained from blood bank charts, intraoperative and PICU observation charts. Demographic data, intraoperative details and post-operative blood product use were extracted from patient records and entered in a standardised case record form. Fifty three percent of children received blood products following cardiac surgery. The blood products transfused included cryoprecipitate (30.9%), packed red cells (22.2%), albumin (18.3%), fresh frozen plasma FFP (15.9%) and platelet concentrate (15.1%). Low haemoglobin level was commonest indication (86%) for red cell use. Bleeding was the commonest indication for FFP (70%) and cryoprecipitate (67%) use. Thrombocytopenia was the commonest indication (84%) for platelet use while hypotension episodes were predominant (95%) in those who received albumin. The standardized mortality ratio was 3.1 vs 0, respectively, among transfused versus non-transfused patients (p<0.0001). The median (IQR) duration of PICU stay was 5 (3-11) vs 2 (2-5) days, respectively in those transfused versus non-transfused (p<0.0001). The median (IQR) ventilation duration was 47(22-132) hours vs 20 (6-27) hours, respectively among the transfused versus non-transfused (p=<0.0001). The factors associated with blood-product use post cardiac surgery include previous cardiac surgery, younger age, lower weights, and prolonged coagulation parameters (p=<0.05). Conclusion- There is high usage of blood products among children post cardiac surgery. The children transfused had a longer ICU stay, ventilation duration, and higher standardized mortality ratio compared to the non-transfused.

Introduction: Congenital and acquired heart diseases are highly prevalent in developing countries despite limited specialised care. Namibia established a paediatric cardiac service in 2009 with significant human resource and infrastructural constraints. Therefore, patients are referred for cardiac interventions to South Africa. Objectives: To describe the diagnoses, clinical characteristics, interventions, post-operative morbidity and mortality and follow-up of patients referred for care. Methods: Demographics, diagnoses, interventions, intra- and postoperative morbidity and mortality as well as longitudinal follow-up data of all patients referred to South Africa were recorded and analysed. Results: The total cohort constituted 193 patients of which 179 (93%) had congenital and 7% acquired heart disease. The majority of patients (78.8%) travelled more than 400 km to Windhoek prior to transfer. There were 28 percutaneous interventions. Palliative and definitive surgery was performed in 27 and 129 patients respectively. Eighty (80/156, 51.3%) patients had postoperative complications, of which 15 (9.6%) were a direct complication of surgery. Surgical mortality was 8/156 (5.1%, 95% confidence interval 1.2.2-9.8), with a 30- day mortality of 3.2%. Prolonged ICU stay was associated with a 5% increased risk of death (Hazard Ratio 1.05, 95% confidence interval: 1.02-1.08, p=0.001). Follow-up was complete in 151 (78%) patients over seven years. Conclusions: Despite the challenges associated with a cardiac programme referring patients for intervention to a neighbouring country and the adverse characteristics of multiple lesions and complexity associated with late presentation, we report good surgical and interventional outcomes. Our goal remains to develop a comprehensive sustainable cardiac service in Namibia.

Introduction: Hospital acquired infections (HAIs) are an important cause of morbidity and mortality following paediatric cardiac surgery. Aim: To determine the incidence, risk factors for and outcome of postoperative HAIs in the Paediatric Intensive Care Unit (PICU) of the Red Cross War Memorial Children's Hospital (RCWMCH) in Cape Town. Methods: A prospective observational study of all postoperative cardiac patients admitted to PICU from September 2011 to March 2012. The definitions of laboratory confirmed blood stream infections (BSI), urinary tract infections (UTI), and surgical site infections were based on the Centres of Disease Control criteria. Ventilator associated pneumonia (VAP) was diagnosed using a modification of the Clinical Pulmonary Infection Score (CPIS). Results: 110 patients (median age 19 months; 43% male) undergoing 126 surgical procedures were enrolled. Sixty HAIs occurred in 43 (39%) patients (68.3% pulmonary; 13.3% blood; 11.7% wound; 3.3% urine; 3.3% tissue). Nine (8.2%) patients died and their deaths were not related to HAIs.

Poor communication is identified as the root cause for the majority of sentinel events in hospitals, including wrong site surgery, medication errors, and failure to rescue. Interdisciplinary rounding (IDR), a long-standing practice in the Intensive Care Unit (ICU), provides a forum for communication and collaboration and has been linked to improved patient outcomes. Most of the research regarding IDR has been performed in the ICU setting within academic medical centers. IDR outside of the ICU has demonstrated similar clinical outcomes but a gap exists in the literature regarding the impact of IDR participation on the nurse, particularly for nurses working in the non-ICU setting within community hospitals. This led to the development of a research question. Basic Psychological Needs Theory was chosen as the theoretical framework – to specifically assess how participation in IDR affected the nurses' sense of autonomy, competence, and relatedness. A mixed method study was conducted in a community hospital in Central Florida using surveys and semi-structured interviews. Results indicated ICU nurses perceived a higher level of collaboration with physicians than nurses working outside of the ICU but this did not correlate with satisfaction of the ICU nurses' basic psychological needs. Only the nurses' level of experience and advanced nursing education appeared to have any significant impact on satisfaction of the nurses' basic psychological needs. The interview responses confirmed the presence of different rounding processes and levels of collaboration outside of the ICU, which helped to explain and support study outcomes. Opportunities for process improvements were also identified.

Healthcare systems have been demonstrably altered because of the COVID-19 pandemic. Resources were stretched and patient conditions deteriorated on a scale previously unseen, leaving nurses at the forefront to face the adversities brought about by the pandemic. In this study, a questionnaire was utilized to better understand how COVID-19 has impacted the stress level, resilience/well-being, moral distress, job satisfaction/enjoyment, practice environment, and intent to remain in the nursing profession of nursing alums from East Tennessee State University. This study focused on a subset of nurses working in critical care, to consider the impact that the pandemic had on ICU nurses’ emotional well-being and job enjoyment. This study collected general demographics and information regarding how each participant’s work was impacted as a result of COVID-19. The Practice Environment Scale of the Nursing Work Index (PES-NWI) questionnaire, Job Enjoyment Scale (JES), and Professional Quality of Life (Pro-QOL) scales were also leveraged to gain an understanding of the participants’ perspectives on their work and mental situations. The results showed that critical nurses generally answered more negatively on the PES-NWI, JES, and ProQOL scales. The study concludes that ICU nurses have lower emotional well-being and job enjoyment than nurses in general and may have been more greatly impacted by the COVID-19 pandemic.