A continuous load path in a structure is always the best way to transmit the load from the upper story to the foundation. However, there is a tradition of using irregular shapes of structures nowadays to enhance the aesthetic, make a terrace, or for getting sunlight. This irregular shape disrupts the continuous load path of the structure and there is the formation of a high-stress zone in the structure which may lead to failure in case of extreme events. During the event of an earthquake, a structure that has an irregularity in its mass, stiffness, and strength suffers more damage as compared to its regular counterpart. So, we need to pay more attention while designing the irregular structure so that it can withstand the force acting on it and ensure the safety of people. So, in this thesis, the seismic response of structures with vertical irregularity is studied. For this purpose, the fundamental time periods of the structures with vertical irregularity are studied and compared with their regular structure. The obtained result is compared with the approximate fundamental period, Ta, given by ASCE/SEI 7-16. Also, the location of critical columns which has the highest load ratio is studied and designed.