Submitted by Jailda Nascimento (jmnascimento@pucsp.br) on 2016-10-06T19:10:42Z No. of bitstreams: 1 Ana Luiza Bringuente.pdf: 3398199 bytes, checksum: 886e050b674aa1d91d175f7e827d0d18 (MD5) / Made available in DSpace on 2016-10-06T19:10:43Z (GMT). No. of bitstreams: 1 Ana Luiza Bringuente.pdf: 3398199 bytes, checksum: 886e050b674aa1d91d175f7e827d0d18 (MD5) Previous issue date: 2016-08-11 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This research proposes some situated investigations in the field of contemporary experimentation on the communicative relationships of art education with contemporary art agents, showing the results obtained in these interactions, intending to facilitate a reflection on networking as new meanings generator. The question for triggering the search was "How can you make art education practices in contact with other agents of contemporary art? ". Therefore, situations were elected in the history of museums and their relationship with the visitors, through a brief history of art education with worldwide references to the Brazilian context of art education in museums to then propose a cut in production artists and other agents of the contemporary art of the 1960-70s that in their practices appropriated issues relevant to the field of art education which will reverberate in contemporary production from the phenomenon called Educational Turn. The light of the thought of C. Salles and V. Colapietro about the concept of authorship comprising the subject as a community, as a result of research we come to a presentation of Luis Camnitzer production that makes its artistic and reflective practices since the 1960s until today a hybrid way from its various performances, as an educator, theorist of art and pedagogical curator, of which he makes no distinction, since all they ever go away from your artist point of view. All this route is necessary with the purpose of giving light to the last chapter of the research where we relate some personal experiences in the field of art education with the practices presented during the research. The methodology used for the research was documentary and empirical, in dialogue with the theory of network creation processes (SALLES). Among the hypotheses, I can highlight that I think are important: the production and reflection on contemporary art through works / jobs supported in art education proposals is feasible; the Pedagogical Curator enhances public access to exhibitions and public programs; the role of art education as a field of knowledge and research into the system of contemporary art / A presente pesquisa propõe algumas investigações situadas no campo da experimentação contemporânea sobre as relações comunicativas da arte educação com agentes da arte contemporânea, evidenciando os resultados adquiridos nessas interações, pretendendo viabilizar uma reflexão sobre o trabalho em rede como gerador de novos sentidos. A pergunta disparadora para a pesquisa foi “Como se dão as práticas da arte educação em contato com outros agentes da arte contemporânea? ”. Para tanto, partimos da eleição de situações ao longo da história dos museus desde o seu surgimento e relação com o público visitante, passando por um breve histórico da educação de arte com referências mundiais até o contexto brasileiro de arte educação em museus para, assim, propor um recorte na produção de artistas e outros agentes da arte contemporânea dos anos 1960-70 que em suas práticas se apropriaram de questões pertinentes ao campo da arte educação o que irá reverberar na produção contemporânea a partir do fenômeno chamado de Educational Turn. A luz do pensamento de C. Salles e V. Colapietro acerca do conceito de autoria que compreendem o sujeito como comunidade, passamos na sequência da pesquisa a uma apresentação da produção de Luis Camnitzer que faz de suas práticas artísticas e reflexivas, desde nos anos 1960 até os dias atuais um caminho híbrido dentre as suas diversas atuações, como educador, teórico de arte e curador pedagógico, das quais ele não faz distinção, pois todas elas partem sempre de seu olhar de artista. Todo esse percurso se faz necessário com intuito de dar luz ao último capítulo da pesquisa em relaciono algumas experiências pessoais no campo da arte educação com as práticas apresentadas ao longo da pesquisa. A metodologia empregada para a pesquisa foi documental e empírica, em diálogo com a teoria dos processos de criação em rede (SALLES). Dentre as hipóteses, posso destacar as que penso serem importantes: é viável a produção e reflexão acerca da arte contemporânea por meio de obras/trabalhos apoiados em propostas de arte educação; a Curadoria Pedagógica potencializa o acesso do público às exposições e programas públicos; a atuação da arte educação enquanto área de conhecimento e pesquisa no sistema vigente de arte contemporânea

<p dir="ltr">The dissolution profile is one of the most important critical quality attributes (CQAs) for pharmaceutical solid oral dosage forms, as failure to meet the dissolution specification can impact bioavailability. Dissolution tests are essential to assess lot-to-lot product quality and guide the development of new formulations. Therefore, predictive dissolution reduced-order models (ROM) are crucial for the successful implementation of any real-time release testing (RTRT) strategy. Mechanistic and semi-mechanistic ROMs of tablet dissolution for realizing quality by control (QbC) and RTRT frameworks in continuous manufacturing are still scarce or nonexistent. Moreover, realizing the underlying coupled mechanics of wetting, swelling, disintegration, and dissolution is still an open question. This dissertation contributes to developing a mechanistic ROM of pharmaceutical tablet dissolution for the design, optimization, and control of manufacturing processes. We follow several steps towards the progression of the mechanistic model development. First, we develop a semi-mechanistic ROM to capture the relationship between critical process parameters (CPPs), critical material attributes (CMAs), and dissolution profiles. We demonstrate the versatility and the capability of the semi-mechanistic ROM to estimate changes in dissolution due to process disturbances in tablet porosity, lubrication conditions, and moisture content in the powder blend. Next, to understand the underlying coupled mechanism of wetting, swelling, disintegration, and dissolution, we use dynamic micro-computed tomography (micro-CT) with a high temporal resolution to visualize water penetration through the porous network of immediate-release tablets. We couple liquid penetration due to capillary pressure described by the Lucas-Washburn theory with the first-order swelling kinetics of the excipients to provide a physical interpretation of the experimental observations. From the mechanistic understanding of the water penetration kinetics using the micro-CT tests, we propose a two-stage mechanistic ROM, which is comprised of (i) a mechanistic dissolution model of the active pharmaceutical ingredient (API) that solves a population balance model (PBM) for a given API crystal size distribution and dissolution rate coefficient, and (ii) a tablet wetting function that estimates the rate at which the API is exposed to the buffer solution. These two sub-models are coupled by means of convolution in time to capture the start time of the API dissolution process as water uptake, swelling, and disintegration take place. Finally, we demonstrate the versatility and the capability of the mechanistic API dissolution model and the two-stage tablet dissolution ROM to represent the dissolution profile of different pharmaceutical formulations and its connection with CMAs, CPPs, and other CQAs, namely initial API crystal size distribution, porosity, composition, and dimensions of the tablet. In all of the cases considered in this work, the estimations of the model are in good agreement with experimental data. </p>