Thesis (M.S.)--University of Wisconsin--Madison, 1960. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 84-86).

Thesis (M.S.)--Eastern Illinois University, 2009. / Includes bibliographical references.

Inaugural dissertation (Ph. D.)--Friedrich-Wilhelms-Universität zu Berlin, 1933. / Cover title. Bibliography : p. 81-85.

Thesis (Ph. D.)--University of Hong Kong, 2005. / Title proper from title frame. Also available in printed format.

The present work was taken up by me at the suggestion of Professor Sir William Wright Smith and has been done under the guidance and supervision of himself and Dr. P.H.Davis. Taxonomic studies have undergone considerable changes during the last three quarters of a century since the publication of the great Flora Orientalis of Boissier (I867) and the Flora of British India of Hooker f. (1872). Many nomenclatorial changes have been made and the taxonomic status of several species has been clarified in addition to numerous taxa added to our knowledge. Both the above mentioned Floras, therefore, need a complete revision - a fact emphasized by several other taxonomists before Blatter, E. (1930); Chakravarty, H.L. (1948).

Several compounds have been shown to induce the mixed function oxidase enzyme system of animals, and also to inhibit tumor formation. Included in this category are several vegetables and isolated vegetable components from the Cruciferae family. In this study rainbow trout were fed blanched freeze-dried cauliflower, broccoli, or Brussel sprouts at the 20% supplemental level for two months, or 500 ppm benzyl or phenethyl isothiocyanate. At this time the livers were removed and hepatic microsomal enzymes were studied. This treatment did not cause any increases in the metabolism of p-nitroanisole or benzo(a)pyrene and cytochrome P-450 levels were not elevated. On the contrary, benzo(a)pyrene monooxygenase, 7-ethoxycoumarin 0-dealkylase, resorufin 0-dealkylase, p-nitroanisole 0-demethylase, and cytochrome P-450 levels were increased in trout treated orally and intraperitoneally with β-napthoflavone. For all parameters studied, a greater increase in activity was seen in the trout treated intraperitoneally. The vegetable and isothiocyanate supplemented diets also did not inhibit tumor formation in trout challenged with 20 ppb aflatoxin B₁ for one month. A study with rats showed that both blanched freeze-dried cauliflower and air-dried cauliflower cause significant increases in p-nitroanisole 0-demethylase activity and benzo(a)pyrene monooxygenase activity and increased cytochrome P-450 levels in rat hepatic microsomes when fed at the 20% supplemental level for 25 days. It was concluded that the null effects seen with the trout fed the vegetables and isothiocyanates were not due to the heat treatment of the vegetables since rats fed blanched freeze-dried cauliflower had significant increases in enzymatic activity and increased cytochrome P-450 levels over controls. The results of the β-napthoflavone experiment verified the validity and reliability of the experimental assays and conditions and showed that trout hepatic microsomal enzymes can be induced by orally administered compounds. / Graduation date: 1981

In the current research, oil derived from several Brassica species, and related oilseeds, was investigated for use as a lubricant base-oil. Oils obtained from B. rapa L. were selected because of their superior cold temperature performance over Sinapis alba L., B. carinata A., B. napus, and B. juncea L. The commercial antiwear additive zinc dialkyl dithiophosphate (ZDDP) was added (800 ppm) to B. rapa oils to determine the impact on oxidative stability and lubricity. It was found that the B. rapa oil ACS-C7 had a low cloud and pour point. B. rapa oils had poor oxidative stability at 97.8 °C when compared to a mineral oil (petroleum-based) standard. ZDDP had little effect on oxidative stability and cloud point. It was concluded that B. rapa oils have sufficient low temperature performance for use as a lubricant base oil. However, for continued use in a motor oil formulation, further modification of the oxidative stability will be necessary. All B. rapa oils with and without ZDDP were subjected to lubricity testing in a Plint High Frequency Wear Tester (TE-77). Lubricity testing simulates the high temperature and pressure in a motor system. The coefficient of friction and resultant wear scar width were measured. B. rapa oils lower coefficients of friction and decrease wear scar widths when compared with a mineral oil standard. Addition of ZDDP to B. rapa oils slightly increased lubricity performance of the oils. The wear scars produced on the polished stainless steel disk were subjected to X-ray Absorption Near Edge Structure (XANES) analysis using two synchrotron beamlines at the Canadian Light Source. XANES analysis confirmed the presence of a lubricating tribofilm on the surface of the stainless steel disks following B. rapa lubricity testing. These results indicate that B. rapa oils are suitable candidates as lubricant base oils for motor oil formulation.

(Uncorrected OCR) Abstract of thesis entitled SYNTHETIC STUDIES TOWARDS ISAINDIGOTIDIONE Submitted by Poon Ch Yan for the degree of Doctor of Philosophy at The University of Hong Kong in October 2004 Banlangen (WlWMi), more commonly known in the West as baphicacanthus, is a well-reputed traditional Chinese medicinal herbal drug commonly used to treat ailments such as influenza. It was even prescribed recently in Hong Kong for bolstering immunity against the Severe Acute Respiratory Syndrome (SARS) virus. It is the root of Isatis indigotica Fort. (Cruciferae), a biennial plant found along the valley of the Yangtze River (Changjiang) in central China. Isaindigotidione (I) is an alkaloid isolated from the root of I. indigotica. The organic extracts of this root were found to be active in antiendotoxic tests, indicating that isaindigotidione, like other alkaloids from the root, may possess interesting biological activity. As isaindigotidione is found naturally only in small quantities in I. indigotica, further investigation will only be possible when sufficient quantities are synthesized. Chemically, the structure of isaindigotidione is a novel derivative of indolizino[7,6- cjquinoline (II) found in natural and synthetic products for the first time. To our knowledge, no synthetic studies of this compound or its derivatives have yet been reported, and this thesis describes our efforts to synthesize isaindigotidione and its analogues. The main building blocks of the tetracyclic framework II were L-proline (V) and isatin (VI). The acylation of L-proline derivative VII by BOC-protected isatin was achieved under basic conditions to give phenylglyoxylic amide VIII. It was found that, in the presence of base under reflux, VIII underwent bis-cyclization to afford II. It was noted that four transformations (aldol cyclization, dehydration, acylation, and BOC-deprotection) occurred in a one-pot operation very efficiently to produce excellent yields of II. The isaindigotidione analogues III and IV were also synthesized by the same strategy. Substituents at C-7 were introduced by cuprate addition and a Heck reaction to intermediate IX. Epimerization at the C-7 centre was found to occur under the bis-cyclization conditions, and analogues III and IV were obtained as epimeric mixtures. Unfortunately, it was discovered upon extensive investigation that these organometallic conjugate addition reactions did not lend themselves to the addition of the 2,6-dimethoxy-l-phenol moiety to IX and its derivatives, which this retroanalysis indicates is required for the synthesis of isaindigotidione. Several factors were found to deter the addition of the desired substituent, including the steric demands of IX, and the low reactivity of phenyl and aryl organometallic reagents. O. ^N�''/ i H ^O OMe OH OMe II ,NL !""'H ^CH3 i H ^O III IV COOH "N H O^N H VI H .0 OMe OMe � ^ BOC f OMe VII VIII IX / abstract / toc / Chemistry / Doctoral / Doctor of Philosophy

Thesis (Ph. D.)--University of Wisconsin--Madison, 1951. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 67-70).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1964. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 85-89).