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Investigating the role of the lens in the growth and development of the vertebrate eyeWalker, Heather Mhairi January 2014 (has links)
The eye forms through complex tissue interactions, and it still only partly understood. The developing vertebrate lens however, is crucial for coordinating eye development and eye growth, through releasing signals to surrounding eye structures. It is thought that the lens controls the growth of the eye through the production of the vitreous- the jelly-like substance that fills the main cavity of the eye and maintains the eye in its correct shape. Many components of the vitreous are produced by a region of the peripheral retina known as the ciliary body, and so it is believed that the lens controls eye growth through controlling the development of the ciliary body and thus, indirectly, the vitreous. This project addresses this concept. I have identified a previously unknown functional link between the lens and Vitamin A metabolism. The lens is important for maintaining retinoic acid production within the developing chick eye through controlling the expression of RDH10 in the presumptive ciliary body. RDH10 is important for the first step in retinoic acid synthesis, the conversion of Vitamin A into retinal, which is then converted into retinoic acid. The loss of RDH10 within the presumptive ciliary body is associated with a reduction in expression of other genes known to be involved in ciliary body development, BMP7, WNT2B and OTX1 along with a reduction in the growth of the eye. The reduction in retinoic acid production within the eye as a result of lens removal, in turn affects the synthesis of Collagen IX from the ciliary body, a major component of the vitreous. The data suggests that the lens controls retinoic acid production within the eye, through maintaining gene expression in the developing ciliary body. Retinoic acid signalling controls the synthesis of components of the vitreous, such as Collagen IX. The proper accumulation of the vitreous within the eye is crucial for the correct growth of the chick eye.
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Light scattering and light transmission studies of uv-induced protein crosslinking in separated lens crystallins and whole lensesWalker, Marlon LeBrone 08 1900 (has links)
No description available.
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Laser Raman spectroscopic studies of ocular lensesAskren, Carl Colwell 08 1900 (has links)
No description available.
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The photodestruction of tryptophan residues in peptides, proteins and the intact ocular lensTassin, Jeffrey Dale 08 1900 (has links)
No description available.
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Photochemical alterations of ocular lens proteinsHott, John Lester 08 1900 (has links)
No description available.
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Raman spectroscopic/imaging studies of eye lenses and lens proteinsChen, Wen-Lung 12 1900 (has links)
No description available.
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Inductive tissue interaction in the development of the mouse lens in vitroMuthukkaruppan, Veerappan, January 1965 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1965. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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Expression of the Ets family in the lensO'Leary, Christine Marie. January 2005 (has links)
Thesis (M.S.)--University of Delaware, 2005. / Principal faculty advisor: Melinda K. Duncan, Dept. of Biological Sciences. Includes bibliographical references.
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Regulation of beta-B1 crystallin expressionTaube, Jennifer Remington. January 2006 (has links)
Thesis (Ph.D.)--University of Delaware, 2006. / Principal faculty advisor: Melinda K. Duncan, Dept. of Biological Sciences. Includes bibliographical references.
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Identification and functional characterization of cataract-specific gene expression changes reveals important pathways for human lens maintenance, aging and diseaseHawse, John R. January 2004 (has links)
Thesis (Ph. D.)--West Virginia University, 2004. / Title from document title page. Document formatted into pages; contains x, 201 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 185-201).
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