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11	An exploration of some aspects of molecular replacement in macromolecular crystallography Mifsud, Richard William January 2018 (has links) This thesis reports work in three areas of X-ray crystallography. An initial chapter describes the structure of a protein, the methods based on the use of X-rays and computer analysis of diffraction patterns to determine crystal structure, and the subsequent derivation of the structure of part or all of a protein molecule. Work to determine the structure of the protein cytokine receptor-like factor 3 (CRLF3) leading to the successful generation of a structural model of a significant part of this molecule is then described in Chapter 2. A variety of techniques had to be deployed to complete this work, and the steps undertaken are described. Analysis was performed principally using phaser, using maximum likelihood methods. Areas for improvement in generating non-crystallographic symmetry (NCS) operators in existing programmes were identified and new and modified algorithms implemented and tested. Searches based on improved single sphere algorithms, and a new two-sphere approach, are reported. These methods showed improvements in many cases and are available for future use. In Chapter 4, work on determining the relative importance of low resolution and high intensity data in molecular replacement solutions is described. This work has shown that high intensity data are more important than the low resolution data, dispelling a common perception and helping in experimental design.
12	Structural and computational studies of two oligonucleotide modifying enzymes : I-PpoI and T4 polynucleotide kinase / Galburt, Eric A. January 2002 (has links) Thesis (Ph. D.)--University of Washington, 2002. / Vita. Includes bibliographical references (leaves 105-119).
13	Structural insights into glycoprotein transport and viral escape / Velloso, Lucas Malard, January 2004 (has links) Diss. (sammanfattning) Stockholm : Karol inst., 2004. / Härtill 4 uppsatser.
14	Crystallographic studies on redox enzymes containing the thioredoxin fold / Ren, Bin, January 1900 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 1999. / Härtill 4 uppsatser, 1 appendix.
15	Determinants of ligand-induced nuclear receptor activation / Östberg, Tove, January 2004 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.
16	Syntheses of some tri- and tetracyclic heterocycles containing an indole moiety / Engqvist, Robert, January 2004 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
17	Structural studies of lumazine synthases - thermostability, catalytic mechanism and molecular assembly / Zhang, Xiaofeng, January 2005 (has links) Diss. (sammanfattning)--Stockholm : Karol. inst., 2006. / Härtill 4 uppsatser.
18	Catalytic mechanisms and evolution of leukotriene A₄ hydrolyse / Tholander, Fredrik Otto, January 2006 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 6 uppsatser.
19	Mechanistic insights into the biosynthesis of polyketide antibiotics / Sultana, Azmiri, January 2006 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2006. / Härtill 5 uppsatser.
20	Signal transduction by oligomerization structural : and biochemical studies of TRAF6 and Caspase-9 activation / Yin, Qian. January 2008 (has links) Thesis (Ph. D.)--Cornell University, May, 2008. / Vita. Includes bibliographical references (leaves 148-168).

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