This research sought to investigate the phenomenon of strange behaviour related to spirit possession called amakhosi in Mdantsane Township in East London in the Eastern Cape Province of South Africa. This spirit phenomenon has recently been prevalent in Township schools in the Eastern and Western Cape Provinces where school children were said to be possessed by a spirit which caused them to demonstrate a strange kind of destructive behaviour. These occurrences were also reported in the newspapers and community radio stations. All these media communications reported that teachers, parents and community leaders were increasingly concerned over a growing trend wherein children purchase muti called amakhosi which makes them to behave mysteriously and at times climbed school walls with their bear hands and at time becoming violent to the extent of threatening other learners and educators. The informants included community members, learners and educators. In a mainly qualitative research method, empirical data was collected from five selected high schools by means of observations, individual interviews and group discussions. The main aim of this study was to better understand this amakhosi phenomenon and to determine whether it is a spiritual, drug related or a social phenomenon. The findings of the study suggested that amakhosi possession is partly a spiritual phenomenon and should not be overlooked as it can result into serious crimes leading to death just like in the recent cases of satanic killing reported among the youth in South Africa. Secondly, there is also a strong element of drug abuse among the youth associated with amakhosi rituals. Lastly, amakhosi is more than just a spiritual issue. It is a socio-economic problem which mostly involves the youth who are struggling in identifying their roles and positions in the post apartheid South Africa. The main recommendation is that the amakhosi phenomenon needs a „wholistic‟ approach and not to just intervention by involvement of prayers and traditional healers.