Made available in DSpace on 2014-12-17T14:14:05Z (GMT). No. of bitstreams: 1 KattyaGHS.pdf: 407113 bytes, checksum: 7bf14e459b09e873eacee8a4b0b41b74 (MD5) Previous issue date: 2006-08-17 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Investigations in the field of pharmaceutical analysis and quality control of medicines require analytical procedures with good perfomance characteristics. Calibration is one of the most important steps in chemical analysis, presenting direct relation to parameters such as linearity. This work consisted in the development of a new methodology to obtain calibration curves for drug analysis: the stationary cuvette one. It was compared to the currently used methodology, and possible sources of variation between them were evaluated. The results demonstrated that the proposed technique presented similar reproducibility compared to the traditional methodology. In addition to that, some advantages were observed, such as user-friendliness, cost-effectiveness, accuracy, precision and robustness. Therefore, the stationary cuvette methodology may be considered the best choice to obtain calibration curves for drug analyis by spectrophotometry / As investiga??es no campo do controle de qualidade e da an?lise de f?rmacos requerem procedimentos anal?ticos com boas caracter?sticas de desempenho. A calibra??o ? uma das etapas mais importantes na an?lise qu?mica, apresentando a rela??o direta aos par?metros tais como linearidades. Este trabalho consistiu no desenvolvimento de uma metodologia nova para obter curvas de calibra??o para a an?lise de f?rmaco: a cubeta estacion?ria. Foi comparado ? metodologia atualmente usada, e as fontes poss?veis da varia??o entre elas foram avaliadas. Os resultados demonstraram que a t?cnica proposta apresentou par?metros semelhantes ? metodologia tradicional. Al?m de algumas vantagens como facilidade na execu??o, baixo custo, exatid?o, precis?o e robustez. Conseq?entemente, a metodologia da cubeta estacion?ria pode ser considerada como metodologia de escolha para obter curvas de calibra??o para a an?lise de f?rmacos por espectrofotometria