Background: Jojoba butter is cyanogenic and has gained attention among herbal supplement consumers due to claims that it may aid in weight loss. Jojoba butter is extracted from the seeds of jojoba shrubs found in the Sonoran Desert. The seeds have long been recognized as inedible, however clinical symptoms following ingestion are not well documented. Case report: This report describes a patient who developed restlessness and gastrointestinal complaints following ingestion of homemade jojoba seed butter. The patient's presentation following ingestion is discussed, as well as effective workup and treatment. In our case, the patient was monitored and received fluid resuscitation, lorazepam, and diphenhydramine for symptomatic therapy. Conclusion: This case describes the gastrointestinal sequela and effective management following ingestion of jojoba butter.

Orientador: José Roberto Bosqueiro / Resumo: O termo Diabetes mellitus (DM) descreve uma desordem metabólica, caracterizada por hiperglicemia crônica, resultante da falta de produção de insulina e/ou de resistência à ação do mesmo. Atualmente, muitos medicamentos são utilizados para tratar diabetes, incluindo insulina exógena e drogas alopáticas como biguanidas, sulfonilureias e inibidores de alfa-glicosidases. Entretanto, possuem muitos efeitos adversos que diminuem a qualidade de vida do paciente e a resposta por uso prolongado. Somado ao fato de que a incidência do DM vem se elevando de modo alarmante, os estudos com plantas que possuam efeitos antidiabéticos vêm despertando o interesse por parte dos pesquisadores. Estudos anteriores do nosso grupo de pesquisa sobre o efeito hipoglicemiante do extrato de folhas de Bauhinia holophylla nos permitiu identificar e isolar a molécula responsável pelo efeito hipoglicemiante. Tal molécula é denominada litospermosídeo, um cianoglicosídeo não- cianogênico. Assim, o presente estudo teve como objetivo realizar a caracterização geral do efeito do litospermosídeo no quadro diabético de camundongos diabéticos induzidos por estreptozotocina e tratados por 14 dias nas doses 1, 5, 10 e 20mg/Kg, na busca de uma alternativa para o tratamento do diabetes. Foram utilizados camundongos machos Swiss, que foram separados em 1 grupo normoglicêmico e 5 grupos diabéticos. A glicemia de jejum mensurada nos dias 7 e 14, e a ingestão hídrica e alimentar e o peso corpóreo foram medidos diariamente.... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The term Diabetes mellitus (DM) describes a metabolic disorder characterized by chronic hyperglycemia resulting from lack of insulin production and/or resistance to insulin action. Many medications are currently being used to treat diabetes, including exogenous insulin and allopathic drugs such as biguanides, sulfonylureas, and alpha-glycosidase inhibitors. However, they have many adverse effects that decrease the quality of life of the patient and the response for prolonged use. In addition to the fact that the incidence of DM is rising alarmingly, studies with plants that have anti-diabetic effects have aroused the interest of the researchers. Previous studies by our research group on the hypoglycemic effect of Bauhinia holophylla leaf extract have allowed us to identify and isolate the molecule responsible for the hypoglycemic effect. Such a molecule is called lithospermoside, a noncyanogenic cyanoglicoside. The aimed of this study was to characterize the lithospermoside effect in the diabetic group of diabetic mice induced by streptozotocin and treated for 14 days at doses 1, 5, 10 and 20mg / kg, in the search for an alternative treatment of diabetes. Male Swiss mice were used, which were separated into 1 normoglycemic group and 5 diabetic groups. Fasting glycemia measured on days 7 and 14, and water and food intake and body weight were measured daily. On the 14th day, insulin sensitivity and glucose tolerance were analyzed. After 14 days, the animals were euthanized and ... (Complete abstract click electronic access below) / Mestre